The crystal structures of the new compounds spiro[cyclohexane-1,3’-indol]-2’(1’H)-one (1), (rel-1R,2S)-spiro[bicyclo[2.2.1] heptane-2,3’-indol]-2’(1’H)-one (2) and spiro[indole-3,2’-tricyclo[3.3.1.1]decan]-2(1H)-one (3) have been determined by low temperature single crystal X-ray diffraction. The effects of substitution on the hydrogen bonding pattern is compared between all three compounds.

An excessive production of indol in the intestine, manifested by increased elimination of indoxyi sulphate or indican in the urine occurs in a number of diseases. The causation of functional nervous disorders among others has been ascribed more than once to indol poisoning, and it is a fact of every-day laboratory observation that the urine of those suffering from migraine or “the blues” and th...

The acid in the commonly used indol reagent described by Kovacs (1928, 1932) and Diagnostic Procedures and Reagents (1950) changes the reaction of the medium in which the indol production is tested and prevents the further observation of biochemical processes, killing the bacteria themselves. It was found that, by heating 0.1 ml. or less of culture (broth or peptone water), indol production by ...

A new series of 6,8-halo-substituted-2H-[1,2,4]triazino[5,6-b]indole-3(5H)-one/-thione and 6,8-halo-substituted 5-methyl-2H-[1,2,4]triazino[5,6-b]indol-3(5H)-one/-thione (5a-5l) were designed and synthesized keeping in view of the structural requirement of pharmacophore. The above compounds were characterized by thin layer chromatography and spectral analysis. Anticonvulsant activity of the syn...

To elucidate the mechanism of the tension staircase, chick embryonic myocardial cell aggregates were loaded with the fluorescent cytosolic calcium indicator, indol. Fluctuations in indol fluorescence were compared with recordings of cell edge movement during spontaneous beating and during stimulation by intracellular current pulses. Indol-loaded aggregates exhibit fluorescence transients during...

Based on a known pharmacophore model for 5-HT₆ receptor antagonists, a series of novel extended derivatives of the N-arylsulfonyindole scaffold were designed and identified as a new class of 5-HT₆ receptor modulators. Eight of the compounds exhibited moderate to high binding affinities and displayed antagonist profile in 5-HT₆ receptor functional assays. Compounds 2-(4-(2-methoxyphenyl)piperazi...

Newly synthesized 2-(2-((1H-indol-5yl)methylene)-hydrazinyl)-thiazole derivatives were evaluated for their in vitro cytotoxicity on two carcinoma cell lines A2780 and HeLa. Significant cytotoxic activity for 2-(2-((1H-indol-5-yl)methylene)hydrazinyl)-4-methylthiazole (1) and 2-(2-((1H-indol-5-yl)methylene)hydrazinyl)-4-phenylthiazole (3), on both A2780 [IC50: 11.6 μM (1), and 12.4 μM (3)] and H...

An excessive production of indol in the intestine, manifested by increased elimination of indoxyi sulphate or indican in the urine occurs in a number of diseases. The causation of functional nervous disorders among others has been ascribed more than once to indol poisoning, and it is a fact of every-day laboratory observation that the urine of those suffering from migraine or “the blues” and th...