indole is a nitrogen-containing heterocycle. it is a very important motif in agriculture and pharmacy. many compounds containing indole moiety has been isolated form nature. it is also an important part in natural alkaloids. tryptophan is an amino acid which posses indole. 3-sustituted indoles are the main group of its derivatives. because the wide-spread application of 3-substituted indolic co...

Various indolyl chalcones have been synthesized in unsealed vessels in a domestic microwave oven. Considerable increase in the reaction rate has been observed with better yields.

A simple and efficient method for the synthesis of 3-indolyl-3-hydroxy oxindoles and unsymmetrical 3,3-di(indolyl)indolin-2-ones using microwave irradiation without catalyst and solvent is described. A series of 3-indolyl-3-hydroxy oxindoles and unsymmetrical 3,3-di(indolyl)indolin-2ones have been synthesized in very short reaction times of 5 and 10 minutes and in yields ranging from 31% to 98%...

The study synthesized a supramolecular complex of glycyrrhizic acid and β -indolyl-3-acetic in 4:1 ratio isolated from the root plant licorice (Glycyrrhiza glabra L.). resulting GA:IAA (4:1) was chemically identified based on comparison IR – Fure spectra starting agents.

Chiral squaramides are highly enantioselective catalysts for Friedel-Crafts reaction of indoles with N-tosyl imines, affording 3-indolyl methanamine products in 85-96% yields and 84-96% ees.

An improved and practical synthesis of substituted quinolines and bis(indolyl)methanes was achieved under microwave condition using Zn(OTf)(2) as catalyst. The synthesized compounds have been screened for antimicrobial and antioxidant activities.

Human ribonucleotide reductase (hRR) is the key enzyme involved in de novo dNTP synthesis and thus represents an important therapeutic target against hyperproliferative diseases, most notably cancer. The purpose of this study was to evaluate the ability of non-natural indolyl-20-deoxynucleoside triphosphates to inhibit the activity of hRR. The structural similarities of these analogues with dAT...

benzyltriphenylphosphonium bromide (btpb) has been applied as an efficient catalyst for the preparation of bis(indolyl)methanes (bims) via electrophilic substitution of indoles with aldehydes in the absence of solvent.

an efficient and convenient protocol for synthesis of 3-hydroxy-3-indolyl-2-oxindoles and 3,3-diindolyl-2-oxindoles is presented here. the syntheses were achieved selectively under catalysis of liclo4 whereby the products were obtained purely.