Chemotherapy regimens for pancreatic ductal adenocarcinoma (PDAC) have changed since the introduction of FOLFIRINOX. Due to toxicity, dosage and number of applied cycles are limited. In analogy to chemotherapy strategies in colon cancer we used a scheme of induction, maintenance and re-induction therapy in PDAC to alleviate such toxicities and increase the number of applied cycles. Here we repo...

Background: The induction chemotherapy regimen for acute myeloid leukemia has evolved as once induction is completed patients progress through the consolidation phase and achieve remission in 76% of cases. For patients with relapsed or refractory disease, alternative chemotherapy agents are available. Monoclonal antibody therapy with biological agents, such as the immunotoxin gemtuzumab ozog...

The study attempted to assess the effectiveness of two devices in facilitating the induction of hypnosis in subjects preselected as low in hypnotizability. Undergraduates were exposed to no treatment (control) or one of four combinations of devices during the induction phase of being administered the Stanford Hypnotic Susceptibility Scale, Form B of Weitzenhoffer and Hilgard (1959). Analyses re...

background: bone marrow stromal cells (bmsc) are used as a source for cell therapy in different model for neurological disorder such as stroke and spinal cord injury. however, the transdifferentiation of bmsc into cholinergic phenotype requires more investigation. methods: bmsc were isolated from adult rats, pre-induced with β-mercaptoethanol (bme) and followed by nerve growth factor (ngf) indu...

STUDY POPULATION. This study was a nonrandomized controlled, parallel-group intervention trial with an active study population of 50 consecutively enrolled children aged 5 to 18 years. The study children underwent egg OIT after confirming immunoglobulin (Ig)E-mediated egg allergy by using a double-blind, placebo-controlled egg food challenge (DBPCFC). The control group included 32 children who ...

STUDY POPULATION. This study was a nonrandomized controlled, parallel-group intervention trial with an active study population of 50 consecutively enrolled children aged 5 to 18 years. The study children underwent egg OIT after confirming immunoglobulin (Ig)E-mediated egg allergy by using a double-blind, placebo-controlled egg food challenge (DBPCFC). The control group included 32 children who ...

A 70-year-old male with hypertension, ischemic cardiac diseaseand a chronic kidney disease due to membranous nephropathy, received KT from controlled death donor. He as induction therapy basiliximab.

Introduction: Glucocorticoids are considered the cornerstone of the induction phase in all treatment protocols of acute lymphoblastic leukemia (ALL). Among the adverse effects of high-dose glucocorticoid treatment, adrenal insufficiency is secondary to suppression of the hypothalamic-pituitary-adrenal (HPA) axis. This drawback of exogenous steroid therapy gains a contemporary particular relevan...

the present treatment goals for inflammatory bowel diseases (ibd) especially ulcerative colitis (uc) include rapid induction of clinical remission, steroid-free maintenance of clinical remission, mucosal healing and improvement of quality of life in uc patients. immunomodulators have been reserved for steroid- dependent or steroid- refractory uc patients. among these agents, azathioprine/6-merc...

Abstract The role of surgery, chemotherapy, and radiation therapy for retinoblastoma has evolved considerably over the years with efficacy intraarterial chemotherapy high incidence secondary malignant neoplasms following therapy. use spot scanning intensity‐modulated proton may reduce risk malignancies. For pediatric nasopharyngeal carcinoma, current standard care is induction followed by chemo...