Chu PL, Keum S, Marchuk DA. A novel genetic locus modulates infarct volume independently of the extent of collateral circulation. Physiol Genomics 45: 751–763, 2013. First published June 25, 2013; doi:10.1152/physiolgenomics.00063.2013.—In the mouse model of permanent, middle cerebral artery occlusion, infarct volume varies widely across inbred strains but generally is inversely correlated with...

BACKGROUND AND PURPOSE This study was designed to analyze whether early diffusion-weighted imaging (DWI) provides reliable quantitative information for the prediction of stroke patients at risk of malignant brain infarct. METHODS We selected 28 patients with a middle cerebral artery (MCA) infarct and proven MCA or carotid T occlusion on DWI and MRI angiography performed within 14 hours after ...

Background and Purpose—In ischemic stroke, MR perfusion-weighted imaging (PWI) and diffusion-weighted imaging (DWI) mismatch represents tissue at risk for infarction. Infarct growth should only take place in the presence of mismatch, although there have been reports of this occurring. We hypothesized that this observation may be attributable to the presence of undetected “hidden mismatch,” whic...

BACKGROUND Imaging is used as a surrogate for clinical outcome in early-phase stroke trials. Assessment of infarct growth earlier than the standard 90 days used for clinical end points may be equally accurate and more practical. OBJECTIVE To compare assessment of the effect of reperfusion therapies using 24-hour vs day 90 magnetic resonance imaging. DESIGN Infarct volume was assessed on dif...

OBJECTIVE To assess the utility of multiphasic perfusion CT in the prediction of final infarct volume, and the relationship between lesion volume revealed by CT imaging and clinical outcome in acute ischemic stroke patients who have not undergone thrombolytic therapy. MATERIALS AND METHODS Thirty-five patients underwent multiphasic perfusion CT within six hours of stroke onset. After baseline...

BACKGROUND AND PURPOSE Infarct volume may predict clinical outcome in acute stroke, but manual segmentation techniques limit its routine use. We hypothesized that computer-assisted volumetric analysis to quantify acute infarct volume will show no difference compared with manual segmentation but will show increased speed of performance and will correlate with outcome. MATERIALS AND METHODS Pat...

BACKGROUND AND PURPOSE C-arm flat detector CT parenchymal blood volume imaging allows functional assessment of the brain parenchyma in the neurointerventional suite. This study aimed to determine the optimal C-arm flat detector CT parenchymal blood volume thresholds for demarcating irreversibly infarcted brain parenchyma by using areas of restricted diffusion on MR imaging as a surrogate marker...

BACKGROUND Computed tomography perfusion (CTP) is increasingly being used in the setting of acute ischemic stroke (AIS). The aim of the current study was to compare the prognostic utility of, and inter-observer variation between, baseline appearances on non-contrast CT (using Alberta Stroke Program Early CT score(ASPECTS)) and on CTP for predicting final infarct volume. We also assessed impact ...

The volume of acute ischemic infarcts has been shown to correlate with stroke severity and functional outcomes in all subtypes of ischemic stroke. In patients with lacunar stroke, infarct size in conjunction with infarct location has been proposed to distinguish this subtype from other forms of subcortical ischemic stroke. Most lacunar infarcts are caused by occlusion of the penetrating small v...

OBJECTIVE Within the context of a prospective randomized trial (SWIFT PRIME), we assessed whether early imaging of stroke patients, primarily with computed tomography (CT) perfusion, can estimate the size of the irreversibly injured ischemic core and the volume of critically hypoperfused tissue. We also evaluated the accuracy of ischemic core and hypoperfusion volumes for predicting infarct vol...