AIM To determine the association between feelings of inferiority and suicidal ideation and suicide attempt among youth in the United States. METHODS Data were drawn from the National Comorbidity Survey carried out among a representative sample of the 15-54 year old population (n=8,098) in the United States. The subsample analyzed in this study included 1,456 respondents aged 15-19. Multivaria...

Two approaches of multiple decision processes are proposed for unifying the non-inferiority, equivalence and superiority tests in a comparative clinical trial for a new drug against an active control. One is a method of confidence set with confidence coefficient 0.95 improving the conventional 0.95 confidence interval in the producer's risk and also the consumer's risk in some cases. It require...

China’s military planners like to claim that in overall terms, the PLA is technologically inferior if compared with its potential adversaries. Such inferiority will continue in the foreseeable future, even though the People’s Liberation Army (PLA) has made some progress in modernizing its weaponry in recent years. On the other hand, the strategic principles of the PLA have undergone a major shi...

Switching between testing for superiority and non-inferiority has been an important statistical issue in the design and analysis of active controlled clinical trial. In practice, it is often conducted with a two-stage testing procedure. It has been assumed that there is no type I error rate adjustment required when either switching to test for non-inferiority once the data fail to support the s...

BACKGROUND A two-arm non-inferiority trial without a placebo is usually adopted to demonstrate that an experimental treatment is not worse than a reference treatment by a small pre-specified non-inferiority margin due to ethical concerns. Selection of the non-inferiority margin and establishment of assay sensitivity are two major issues in the design, analysis and interpretation for two-arm non...

this article studies the depiction of chinese miners in the ghanaian news website entitled modern ghana. a total of 87 articles comprising 43752 words were retrieved. van leeuwen’s (2008) theory of the representation of the social actors was utilised to examine the depiction of chinese miners in the ghanaian press. in this regard, six applicable tools were used and these include exclusion, role...

BACKGROUND Current regulatory guidance and practice of non-inferiority trials are asymmetric in favor of the test treatment (Test) over the reference treatment (Control). These trials are designed to compare the relative efficacy of Test to Control by reference to a clinically important margin, M. MAIN TEXT Non-inferiority trials allow for the conclusion of: (a) non-inferiority of Test to Con...

BACKGROUND Non-inferiority clinical trials (NIFCTs) aim to demonstrate that the experimental therapy has advantages over the standard of care, with acceptable loss of efficacy. We evaluated the purposes underlying the selection of a non-inferiority design in oncology and the size of their non-inferiority margins (NIFm's). PATIENTS AND METHODS All NIFCTs of cancer-directed therapies and suppor...