Early in the study of mammary carcinoma in mice attention was given to the correlation of mammary gland structure and the occurrence of malignant growth. Haaland (31), in a rather extensive study, emphasized the frequency with which small adenomatous areas, previously described by Apolant (6), were encountered in the glands of mice with mammary carcinoma as compared with those of mice dying wit...

Abstract Mammary gland tumor is rare and only a few cases have been reported in wild animals. Moreover, most etiologies of the known veterinary medicine are related to age, diet, obesity, excessive sex hormones domestic animals while An unknown-aged female boar was presented Department Veterinary Pathology, Kyungpook National University with well-demarcated, firm-to-elastic mammary mass. The cu...

Breast cancer incidence increases during aging, yet the mechanism of age-associated mammary tumorigenesis is unclear. Mammary stem cells are believed to play an important role in breast tumorigenesis, but how their function changes with age is unknown. We compared mammary epithelial cells isolated from young and old mammary glands of different cohorts of C57BL6/J and BALB/c mice, and our findin...

despite of the fact that the vulva contains a high density of apocrine and anogenital mammary glands in addition to eccrine glands and folliculosebaceous units, the benign vulvar adnexal tumours are rare. though the varied clinical presentation and diverse histopathological spectrum of vulvar neoplasms has amazed the pathologists, only few studies have been reported in literature. the present f...

fibroadenoma of the vulva is an uncommon lesion. it has been suggested that they originate from vulvar mammary like other glands. a few examples of benign and malignant vulvar tumors arising from such glands have been reported. a 32-year-old woman was referred with a subcutaneous mass at the vulva. the patient treated by simple excisional surgery with adequate peripheral margin. histological fi...

To investigate the role of membrane-type matrix metalloproteinase-1 (MT1-MMP) in mammary gland development and tumorigenesis, transgenic mice overexpressing MT1-MMP in mammary gland under the control of the mouse mammary tumor virus long terminal repeat-promoter were generated. The mouse mammary tumor virus/MT1-MMP transgenic mice displayed abnormalities in 82% of female mammary glands. The abn...

The administration of large doses of estrogen to young male mice was followed by less extensive mammary gland growth than when small amounts of estrogens were given". The areas occupied by the mammary glands of the mice given large doses were often but little larger than the glands of untreated controls, but unlike the controls their mammary glands, although very small, had a few alveoli on the...

A conditional null mutation of peroxisome proliferator-activated receptor-binding protein (PBP) gene was generated to understand its role in mammary gland development. PBP-deficient mammary glands exhibited retarded ductal elongation during puberty, and decreased alveolar density during pregnancy and lactation. PBP-deficient mammary glands could not produce milk to nurse pups during lactation. ...

Administration by stomach tube of 86-50 doses of 5 mg. of ~0-methylcholanthrene to Syrian golden hamsters resulted in the occurrence of squamous-cell tumors of the forestomach, adenocarcinomas of the small and large intestine, adenocarcinomas of the mammary glands, thecomas of the ovaries, and sebaceous tumors of the skin and ear duct glands. Of these types of tumors, only a few squamous-cell p...

This paper investigates the association between expression of CD14 and occurrence of apoptosis in blood monocytes, resident (RESMAC) and inflammatory macrophages from heifer mammary glands after infusion of PBS (INFMACPBS) or LPS (INFMACLPS). Resident macrophages (RESMAC) were obtained before, and inflammatory macrophages (INFMACPBS and INFMACLPS) 24 h after, induction of an inflammatory respon...