OBJECTIVE: To present a review about inflammatory bowel diseases in childhood so that pediatricians become familiar with two diseases (ulcerative colitis and Crohn s disease) that are increasing in incidence. METHODS: Articles of specific gastroenterological journals were analyzed. Information was also obtained from the author s extensive professional experience in the area. RESULTS: The two di...

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Autophagy provides a mechanism for the turnover of cellular organelles and proteins through a lysosome-dependent degradation pathway. During starvation, autophagy exerts a homeostatic function that promotes cell survival by recycling metabolic precursors. Additionally, autophagy can interact with other vital processes such as programmed cell death, inflammation, and adaptive immune mechanisms, ...

The association of inflammation with modern human diseases (e.g. obesity, cardiovascular disease, type 2 diabetes mellitus, cancer) remains an unsolved mystery of current biology and medicine. Inflammation is a protective response to noxious stimuli that unavoidably occurs at a cost to normal tissue function. This fundamental trade-off between the cost and benefit of the inflammatory response h...

the objective of this study was to evaluate the concentration of these acute phase proteins(serum amyloid a, milk amyloid a and serum haptoglobin) and alteration in hematological values in some inflammatory diseases in dairy cattle. fifty-six holstein dairy cows with some inflammatory diseases were used in this study including: subclinical mastitis, hematological infections (theileriosis and an...

The context in which glaucoma or hypertension in inflammatory diseases is taken care of today has to take into account the tremendous technical developments that have taken place in the last twenty past years or so. These advances are of course not limited to uveitic glaucoma or hypertension but are particularly beneficial in these complex cases where inflammatory and glaucomatous parameters ha...

The three major immune-mediated inflammatory myopathies, dermatomyositis (DM), polymyositis (PM) and inclusion body myositis (IBM), each have their own distinctive clinical features, underlying pathogenetic mechanisms and patterns of muscle gene expression. In DM a complement-dependent humoral process thought to be initiated by antibodies to endothelial cells results in a microangiopathy with s...