AIM To determine factors independently influencing response to ingenol mebutate therapy and assess efficacy on clinical setting of non-hypertrophic non-hyperkeratotic actinic keratosis (AK). METHODS Consecutive patients affected by non-hypertrophic non-hyperkeratotic AKs of the face or scalp were enrolled to receive ingenol mebutate 0.015% gel on a selected skin area of 25 cm2 for 3 consecuti...

• Ingenol mebutate gel (Picato® gel, LEO Pharma, Ballerup, Denmark) is a novel topical self-applied treatment for nonhyperkeratotic, nonhypertrophic actinic keratoses in adults. • Picato gel (0.05%) is applied to trunk and extremity lesions for 2 consecutive days, and at lower strength (0.015%) applied to face and scalp lesions for 3 consecutive days. • The mechanism of action is rapid inductio...

Ingenol mebutate (IM) is a topical pharmacotherapy approved in Switzerland since 2012 for treating non-hypertrophic, non-hyperkeratotic actinic keratosis. We report a case with off-label use of IM where Bowen's disease has been successfully treated with physician-directed IM 0.015% gel under occlusion over the chest area.

Patients suffering from chronic lymphocytic leukemia often develop actinic keratosis (AK) and squamous cell carcinoma in sun-exposed areas. In these particular patients, who have a suboptimal immune function, AK treatment can be particularly challenging. We report the case of a patient who failed to respond to most AK treatments, including 5-FU, imiquimod and photodynamic therapy, but responded...

Herein, we report the case of a 51 year-old Caucasian woman, Fitzpatrick’s skin type III, successfully treated with ingenol mebutate (IM) 0.05% gel on a large-sized(ø 3 cm) superficial BCC (sBCC) localized on the right shoulder. Such lesion appeared as an asymptomatic, irregularly round-shaped patch. The diagnosis was ruled out by clinical and dermoscopic examinations (Figure 1), confirmed by h...

Herein, we report the case of a 51 year-old Caucasian woman, Fitzpatrick’s skin type III, successfully treated with ingenol mebutate (IM) 0.05% gel on a large-sized(ø 3 cm) superficial BCC (sBCC) localized on the right shoulder. Such lesion appeared as an asymptomatic, irregularly round-shaped patch. The diagnosis was ruled out by clinical and dermoscopic examinations (Figure 1), confirmed by h...

Ingenol mebutate (IM) is a topical pharmacotherapy approved in Switzerland since 2012 for treating non-hypertrophic, non-hyperkeratotic actinic keratosis (AK). We report 2 cases with off-label use of IM. The first case of bowenoid AK was treated with 150 μg IM for 3 consecutive days with an almost complete clinical remission of the lesion. The second case of Bowen's disease was treated with 500...