Long QT syndrome (LQTS) is a rare condition that in certain circumstances can lead to severe and potentially lethal cardiac arrhythmia known as Torsade de Pointes (TdP). Inhalational anesthetics are among many medications and conditions known to prolong QT and thus potentially predispose the patient to TdP. Although studies have shown that sevoflurane should be safe for the healthy patients, th...

Corresponding author: Seonghoon Ko, M.D., Ph.D., Department of Anesthesiology and Pain Medicine, Chonbuk National University Medical School and Hospital, 634-18, Keumam-dong, Jeonju 561-712, Korea. Tel: 82-63-250-1979, Fax: 82-63-250-1240, E-mail: [email protected] This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creati...

Background: Inhaled anesthetics are widely used drugs in health centers and hospitals. However, several side effects concerning inhalational anesthetics have been reported. Liver damage is one of the wellknown side effects of inhaled anesthetics and measurement of alkaline phosphatase and alanine aminotransferase serum level is the common method for assessing severity of these damages. Among ho...

The harmful effect of inhalational anesthetics on the working environment of anesthetists is one of most controversial areas, where speculations can easily arise. In the present review the authors summarize the possible sources of environmental pollution in the operating theatre with special emphasis on the importance of air suctioning and air conditioning systems. A full-spectrum of the previo...

conclusions use of inhalational anesthesia has increased in adult cardiac surgery and has proved to reduce duration of elective ventilation, decrease icu and hospital los, and mortality. inhalational anesthetics are less well-studied in cchd. in the current study, desflurane was chosen because of its low solubility, decreased recovery time and lack of metabolism or organ system toxicities. alth...

At surgical depths of anesthesia, inhalational anesthetics cause a loss of motor response to painful stimuli (i.e., immobilization) that is characterized by profound inhibition of spinal motor circuits. Yet, although clearly depressed, the respiratory motor system continues to provide adequate ventilation under these same conditions. Here, we show that isoflurane causes robust activation of CO(...

We describe a genetic and behavioral analysis of several alleles of har38, a mutant with altered sensitivity to the general anesthetic halothane. We obtained a P-element-induced allele of har38 and generated several excision alleles by remobilizing the P element. The mutants narrow abdomen (na) and har85 are confirmed to be allelic to har 38. Besides a decreased sensitivity to halothane, all mu...