conclusions although previous studies have shown that a-g transition mutations in 23 srrna gene (domain v) are the main reason for the occurrence of high level macrolides resistance in b. pertussis, however, the mentioned single nucleotide polymorphisms (snps) have not been detected in our resistant strain. this is the first report of high level macrolide resistant b. pertussis, without snps in...

abstract background: a surgical site infection (ssi) is the most common nosocomial infection after surgery and is the third most common infection in hospitalized patients. the aim of this study was to asses minimum inhibitory concentration (mic) of the causing agents of ssi and antimicrobial susceptibility patterns. methods: this cross-sectional study was done in three referral hospitals in nor...

in this study, we investigated the antifungal effects of silver nanoparticles (ag-nps) on candida albicans (atcc 5027), saccharomyces cerevisiae (atcc 5027). investigating method by using minimum inhibitory concentration (mic) technique, some of drugs including amphotericin b, fluconazole and synthesized ag-nps have been obtained on the fungi and the changes on membrane reactions of yeasts have...

background: embryonic stem cells (esc) are pluripotent cells which have been used as a model to study the mechanism that control the embryogenesis and early mammalian development in vitro. the aim of this study was to isolate and produce embryonic stem cells from late blastocyst stage embryos in mice. materials and methods: blastocyst stage embryos from pregnant nmri mice were obtained and cult...

introduction: gonadotropin inhibitory hormone (gnih) has been known as a key inhibitor of the secretion of gonadotropin releasing hormone (gnrh). ewe has estrous cycles comprising of follicular and luteal phases. follicular phase is in turn divided into proestrous and estrous phases. blood level of lh increases in follicular and decreases in luteal phases. the aim of the present study was to ev...

background: leukemia inhibitory factor (lif) is a 45-56 kda glycoprotein that has an important role in proliferation and embryo implantation. its effect on oocyte maturation and how to exert the function remained to be elucidated. methods: immature mice superovulated with human menopausal gonadotropin and germinal vesicle (gv) oocytes were obtained from ovary 48 hours after. gv oocytes were cul...

neuroserpin, a member of the serine proteinase inhibitor (serpin) superfamily, is known to be a neuroprotective factor in the focal ischemic stroke followed by reducing the microglial activation. neuroserpin is a protein rich of methionine residues that can scavenge the free radical species which may increase its neuroprotective effect. on the other hand, the oxidative modifications of the amin...

background: in this study, the efficacy of nitazoxanide in the treatment of helicobacter pylori isolates, which were resistant to metronidazole, was examined.   methods: one hundred twenty two patients who underwent endoscopy examinations at kasra and laleh hospitals in tehran from november 2014 to july 2015 were enrolled. helicobacter pylori strains were isolated from the patients’ endoscopy b...

emergence of resistance among pathogenic bacteria against available antibiotics is posing a great challenge to the current world. thus, there is a great need to discover novel antibiotics. traditional plants have been proved to be novel source in the search of antimicrobial compounds. the current study pertained to the susceptibilities of some clinically significant bacterial species to various...