BACKGROUND Glucose insulin potassium (GIK) improves hemodynamic performance after coronary artery surgery (CABG). We investigated whether this is associated with changes in gene expression of beta1-adrenergic receptor (ADRB1) or other calcium handling proteins. METHODS AND RESULTS During a randomized double-blind placebo-controlled trial, 48 patients undergoing on-pump CABG, allocated to rece...

BACKGROUND Both glucose-insulin-potassium (GIK) and tri-iodothyronine (T3) may improve cardiovascular performance after coronary artery surgery (CABG) but their effects have not been directly compared and the effects of combined treatment are unknown. METHODS AND RESULTS In 2 consecutive randomized double-blind placebo-controlled trials, in patients undergoing first time isolated on-pump CABG...

BACKGROUND AND OBJECTIVES The benefit of high glucose-insulin-potassium (GIK) solution in clinical applications is controversial. We established a neonatal rat ventricular myocyte (NRVM) in vitro coverslip ischemia/reperfusion (I/R) model and investigated the effects of GIK solution on suppressing reactive oxygen species (ROS) and upregulating O-GlcNacylation, which protects cells from ischemic...

Stress hyperglycaemia is a common event in acute critical illness. There is increasing evidence that maintaining normoglycaemia and treatment with insulin (or with glucose-insulin-potassium [GIK]), even in non-diabetic persons, is helpful in limiting organ damage after myocardial infarction, stroke, traumatic brain injury and other conditions, even though the conditions may be accompanied by in...

Factors influencing the rate of 201Tl clearance from the myocardium have not been clearly defined. This study determined the effect of an intravenous infusion of glucose-insulin-potassium (GIK) on the net 201Tl clearance rates from myocardium with and without initial 201Tl loading. Anesthetized open-chest dogs underwent 5 min of left anterior descending coronary artery occlusion and intravenous...

The effects of glucose-insulin-potassium infusion (GIK) on atrial pacing-induced angina, ST depression, abnormal left ventricular end-diastolic pressure during pacing interruption (LVEDPi) and lactate metabolism (L), were studied in 18 patients: ten had angina during pacing = Ischemic group, and eight (5 normals and 3 with coronary artery disease) remained asymptomatic = Nonischemic group. The ...

BACKGROUND Different protocols have been suggested to treat aluminum phosphide (ALP) poisoning. We aimed to evaluate the possible therapeutic effect of hyperinsulinemia/euglycemia (HIE) in treatment of ALP poisoning. METHODS In a prospective interventional study, a total of 88 ALP-poisoned patients were included and assigned into HIE group undergoing glucose/insulin/potassium (GIK) protocol a...

The effects of infusion of normal saline (NS) and glucose-insulin-potassium (GIK) with either low or high G concentrations on hemodynamics and exercise tolerance were studied in patients with angina pectoris. Studies were performed at rest and during exercise, twice before and once after one of the infusions. Eleven patients (low-G GIK group) received 150 ml of GIK solution that contained 15 g ...

The effects of infusion of normal saline (NS) and glucose-insulin-potassium (GIK) with either low or high G concentrations on hemodynamics and exercise tolerance were studied in patients with angina pectoris. Studies were performed at rest and during exercise, twice before and once after one of the infusions. Eleven patients (low-G GIK group) received 150 ml of GIK solution that contained 15 g ...