The capillary blood glucose response to lmg of intramuscular glucagon was determined in 13 patients with insulinoma and in 33 normal controls; the insulinoma patients showed a normal initial rise, but this was followed by an abnormally large fall, reaching hypoglycaemic levels between 90 and 180 minutes in every case. In 14 insulinoma patients the response of venous blood glucose and also plasm...

The Jagn1 protein was indentified in a SILAC proteomic screen of proteins that are increased in insulinoma cells expressing a folding-deficient proinsulin. Jagn1 mRNA was detected in primary rodent islets and in insulinoma cell lines and the levels were increased in response to ER stress. The function of Jagn1 was assessed in insulinoma cells by both knock-down and overexpression approaches. Kn...

BACKGROUND The time between onset of symptoms of insulinoma to diagnosis ranges from 10 days to more than 20 years. To help physicians make an earlier diagnosis, we defined the clinical, imaging and paraclinical characteristics of insulinoma in cases from seven referral hospitals in Iran over two decades. METHODS The medical records of 68 cases with biochemical or histological evidences of in...

The expression of steroid receptors by tumours offers a therapeutic advantage if functionally responsive to exogenous hormones. Insulinomas represent a highly symptomatic group of pancreatic tumours and the steroid receptor status of these tumours is poorly understood. The object of the study was to characterise the sex steroid receptor status of human insulinomas and to investigate whether sex...

Abstract Nesidioblastosis is a very rare adult disorder in the absence of gastrointestinal surgery. endocrine pancreas causing hyperinsulinemic hypoglycemia. We describe case 83 year-old Caucasian male, with 3-year history severe refractory hypoglycemia glucose level below 2.1 mmol/L. Confusion and sleepiness were reported as his neuroglycopenic symptoms. According to family, symptoms improved ...

Malignant insulinoma is a rare neuroendocrine tumor, located exclusively in the pancreas, characterized by severe hypoglycemia secondary to excessive insulin secretion. Somatostatin analogs (SSA) and everolimus have been added classic treatment with diazoxide last years. Peptide receptor radionuclide therapy (PRRT) has also recently tested few patients apparently satisfactory results. We presen...

We are describing a patient with malignant insulinoma and unusual clinical pathological features. The presented late in the course of disease history abdominal pain was found to have large tumor pancreas metastasis liver. Also, he acute diarrhea which is not feature Insulinoma. During hospital stay had sever hypoglycemia very inappropriately high low blood glucose levels Insulin, C- peptide Pro...

in this report, nine patients with insulinoma who were operated on between 19h5 and i

CONTEXT Insulinoma is an exceedingly uncommon pancreatic islet cell neuroendocrine tumor. Its estimated incidence is approximately four cases per million individuals per year. CASE REPORT We report the case of sporadic insulinoma in an exceptionally very young 10-year-old boy who presented with a 1-month history of episodic tremulousness, diaphoresis, increased hunger, confusion and fainting....