Generalized formulation is developed analytically to calculate the transmission loss performance of a silencer by using multiple micro-perforate panel (MPP) array silencers in ventilation duct system. The device, based on single MPP design, consists of different expansion chambers with the side-branch cavities covered by micro-perforate panels of different properties. The theoretical model can ...

A multi-chamber silencer is designed by a computational approach to suppress the turbocharger whoosh noise downstream of a compressor in an engine intake system. Due to the significant levels and the broadband nature of the source spanning over 1.5 – 3.5 kHz, three Helmholtz resonators are implemented in series. Each resonator consists of a chamber and a number of slots, which can be modeled as...

Kinins are involved in a variety of physiological and pathophysiological processes related to cardiovascular homeostasis, inflammation, blood flow, and nociception. Under physiological conditions, the bradykinin B2 (BKB2) receptor is constitutively expressed and mediates most of kinins' actions. However, the mechanisms regulating BKB2 receptor gene expression are still poorly understood. In thi...

Recent improvements in fiber properties combined with their broadband acoustic dissipation characteristics make such materials potentially desirable for implementation in silencers. The acoustic modelling of simple silencer geometries, such as circular or rectangular cross-sections, has been established and classified depending on the assumption of locallyor bulk-reacting lining. Morse [1] used...

introduction: during the thirty years ago noise pollution increased quickly in the urbane communities that motorcycles are chief sources of noise. the objective of this study is reduction of noise emitted from motorcycle exhaust, applying engineering design. materials and methods: in this pre-experimental study, current condition of noise emitted from motorcycle exhaust and physical parameters ...

CD4(+) helper and CD8(+) cytotoxic T cells differentiate from common precursors in the thymus after T-cell receptor (TCR)-mediated selection. Commitment to the helper lineage depends on persistent TCR signals and expression of the ThPOK transcription factor, whereas a ThPOK cis-regulatory element, ThPOK silencer, represses Thpok gene expression during commitment to the cytotoxic lineage. Here, ...

Submit Manuscript | http://medcraveonline.com Abbreviations: NMD: Nonsense-Mediated mRNA Decay; ISE: Intronic Splicing Enhancer; ESE: Exonic Splicing Enhancer; ISS: Intronic Splicing Silencer; ESS: Exonic Splicing Silencer; PTC: Premature Termination Codon; ASC: Adenosquamous Carcinoma; NAS: Nonsense-associated Altered Splicing; NASRE: NonsenseAssociated Altered Splicing of a Remote Exon; ASO: ...

The HMR-E silencer is a DNA element that directs the formation of silent chromatin at the HMRa locus in Saccharomyces cerevisiae. Sir1p is one of four Sir proteins required for silent chromatin formation at HMRa. Sir1p functions by binding the origin recognition complex (ORC), which binds to HMR-E, and recruiting the other Sir proteins (Sir2p to -4p). ORCs also bind to hundreds of nonsilencer p...

During development of CD4+ T lymphocytes in the periphery, differential expression of cytokine genes, such as those of interleukin (IL)-2 and IL-4, occurs in distinct T-cell subsets. IL-4 is a cytokine produced by T-helper 2 (Th2) cells, and the IL-4 receptor (IL-4R)-mediated signaling pathway is thought to be required for commitment to the Th2 phenotype. However, the molecular basis for develo...