Background: Some tissues in human body are radiobiologically different from water and these inhomogeneity must be considered in dose calculation in order to achieve an accurate dose delivery. Dose verification in complex radiation therapy techniques, such as intensity‐modulated radiation therapy (IMRT) calls for volumetric, tissue equivalent and energy independent dosimeter. The purpose of this...

Introduction: Radiobiological modeling of radiotherapy plans are used for treatment plan comparisons. The current study aimed to compare the three-dimensional conformal radiation therapy (3DCRT) and intensity-modulated radiation therapy (IMRT) plans for nasopharyngeal cancer using radiobiological modeling. Materials and Methods: This study was conducted on 10 patients with nasopharyngeal carci...

Little attention has been paid to the fact that intensity modulated radiation therapy (IMRT) techniques do not easily enable treatment with opposed beams. Three treatment plans (3 D conformal, IMRT, and combined (anterior-posterior-posterio-anterior (AP-PA) + IMRT) of 7 patients with centrally-located lung cancer were compared for exposure of lung, spinal cord and esophagus. Combined IMRT and A...

Intensity modulated radiation therapy (IMRT) and volumetric intensity-modulated arc therapy (VMAT) are two commonly used modalities to treat lung cancer. VMAT has established increasing interest in treating cancer due to shorter treatment delivery time and less number of monitor units (MUs). The main purpose of this article was to review the relevant current literature on planning studies for l...

Radiation therapy has come a long way from treatment planning based on orthogonal radiographs with large margins around tumours. Advances in imaging and radiation planning software have led to three-dimensional conformal radiotherapy and, further, to intensity modulated radiotherapy (IMRT). IMRT permits sparing of normal tissues and hence dose-escalation to tumours. IMRT is the current standard...

We sought to assess the feasibility and estimate the benefit of sparing the neurogenic niches when irradiating the brain of pediatric patients with medulloblastoma (MB) based on clinical outcome data. Pediatric MB survivors experience a high risk of neurocognitive adverse effects, often attributed to the whole-brain irradiation that is part of standard management. Neurogenesis is very sensitive...

This chapter describes the basic principles of intensity-modulated radiation therapy (IMRT), providing the necessary background for subsequent clinical chapters. We start by describing the IMRT treatment planning and delivery process, introducing the wide range of different approaches and technologies currently in clinical use. Then, other topics important in the implementation of IMRT are disc...

introduction: intensity modulated radiation therapy (imrt) is one of the cancer treatment methods. it is important to selectively aim at the target in this way, which can be performed using a multileaf collimator (mlc). materials and methods: in order to specifically irradiate the target volume in radiotherapy to reduce the patient absorbed dose, the use of multileaf collimator has been investi...

Innovation/Impact: We propose a novel delivery method for intensity modulated radiation therapy (IMRT) that significantly reduces treatment delivery times by delivering dose during both inhale and exhale windows. We developed an inverse treatment planning method for developing inhale and exhale IMRT fluence maps that produce a final dose (the summed inhale and exhale doses) that meets clinical ...