The KIX domain is an 89-residues globular domain with an important role in mediating protein-protein interactions. The presence of two distinct binding sites in such a small domain makes KIX a suitable candidate to investigate the effect of the potentially divergent demands between folding and function. Here, we report an extensive mutational analysis of the folding pathway of the KIX domain, b...

T he IT industry has interpreted “personalization” in many ways (D. Riecken,“Personalized Views of Personalization,” Comm.ACM, vol. 43, no. 8,Aug. 2000, pp. 26-28). Personalization refers to the automatic adjustment of information content, structure, and presentation tailored to an individual user. Commercial Web sites increasingly employ personalization to help retain customers and reduce info...

MOTIVATION Large-scale experiments reveal pairs of interacting proteins but leave the residues involved in the interactions unknown. These interface residues are essential for understanding the mechanism of interaction and are often desired drug targets. Reliable identification of residues that reside in protein-protein interface typically requires analysis of protein structure. Therefore, for ...

the interactive effects of adjacent buildings on their seismic performance are not frequently considered in seismic design. the adjacent buildings, however, are interrelated through the soil during seismic ground motions. the seismic energy is redistributed in the neighboring buildings through multiple structure-soil-structure interactions (sssi). for example, in an area congested with many nea...

Multi-environment trials (METs) of crop genotypes are costly and require efficient test sites for cost effectiveness. This study aimed to identify efficient test sites for METs of sugarcane (Saccharum spp.) genotypes in Thailand, utilizing data from 10 sugarcane genotypes conducted at nine locations covering different sugarcane growing regions of the country for two crop-classes. Cluster an...

The complexes of Mn(OAc)3 and/or Mn(acac)3 with nucleic bases and nucleosides (adenine, guanine, xanthine, adenosine and guanosine) have been synthesized in nonaqueous solution. Polarographic and spectroscopic (IR and Visible) methods have been used to establish the active site(s) on the imidazole and pyrimidine rings in the nucleic bases and nucleosides for the intera...