Background:
 Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that affects the joints principally. Synovitis , cartilage and bone erosion are most prominent symptoms of (RA). Stages development this very complex, Synovial cells rupture form inflammation in synovium, followed by deterioration. Cytokines proteins play crucial role onset arise causing progression disease...

Recombinant human interleukin (IL)-11 is a multifunctional cytokine with hematopoietic, immunomodulatory, and epithelial cell protective activities. IL-11alpha receptors are expressed on the luminal surface of intestinal epithelial cells. It was hypothesized that orally administered IL-11 would prevent mucosal damage and protect against microbial invasion in a neutropenic rat model of gram-nega...