A vast amount of work has been dedicated to the effects of hemodynamics and cytokines on leukocyte adhesion and trans-endothelial migration (TEM) and subsequent accumulation of leukocyte-derived foam cells in the artery wall. However, a comprehensive mechanobiological model to capture these spatiotemporal events and predict the growth and remodeling of an atherosclerotic artery is still lacking...

BACKGROUND Melamine and cyanuric acid (M/CA), when orally administered together to rats, can induce crystal formation within renal tubules and cause acute kidney injury. METHODS To investigate the pathomechanism of crystal-induced nephritis, melamine and/or cyanuric acid were administered to 3-week-old (young) and 8-week-old (adult) rats, respectively. RESULTS Crystal formation, blood urea ...

the aim of the present study was to investigate the response of plasma visfatin to resistance exercise intensity and its relationship with insulin resistance, growth hormone and il-6. after familiarization and determining their maximum strength (1-rm), 15 healthy young subjects (age: 26.2±4.1 yr, weight: 75.1±9.1 kg) performed three resistance exercise sessions at intensities of 30%, 55% and 80...

The present study is designed to search for the serum cytokine biomarker for liver injury induced by Dioscorea bulbifera L., which is a traditionally used herbal medicine in China. Mice were orally given various doses of ethyl acetate extract (EF) isolated from D. bulbifera for 12 days. The activity of serum alanine/aspartate transaminases (ALT/AST) was increased in EF (400 mg/kg)-treated mice....

INTRODUCTIION: Interlukin-7 (IL-7) is expressed in osteoarthritis fibroblast-like synoviocytes (hTERT-OA 13A FLS) 8 fold higher than that in rheumatoid FLS (hTERT-RA 516 FLS) (1). Major histocompatibility complex class II protein DP alpha 1 (HLA-DPA1) is also highly expressed in hTERT-OA 13A FLS. Recently, it has been found that IL-7 and its receptor IL-7R are expressed in OA articular chondroc...

Background: Airway epithelial cells may play an important clinical role in the apoptosis of eosinophils. To study recognition pathways, two types of large bronchial airway epithelial cells were used (LAECs and A549). Methods: Both resting, and dexamethasone-stimulated epithelial cells, were used in an inhibition assay. Confocal microscopy was used to demonstrate engulfment of apoptotic eosinoph...