Some in vitro experiments have shown that erythropoietin (EPO) increases resistance to apoptosis and facilitates neuronal survival following cerebral ischemia. However, results from in vivo studies are rarely reported. Perfusion-weighted imaging (PWI) and diffusion-weighted imaging (DWI) have been applied successfully to distinguish acute cerebral ischemic necrosis and penumbra in living animal...

the present study was undertaken to investigate the beneficial effects of widely-prescribed lipid lowering drugs, pitavastatin, atorvastatin and simvastatin 3-hydroxy-3-methylglutaryl-coenzyme-a (hmg-coa) reductase inhibitors in cognitive dysfunctions of mice. intra-cerebroventricular (icv)-streptozocin-(stz)- and high-fat diet (hfd)-induced amnesia served as interoceptive memory models where a...

Although leptin is known to increase sympathetic nerve activity (SNA), we tested the hypothesis that leptin also enhances baroreflex control of SNA and heart rate (HR). Using α-chloralose anesthetized male rats, mean arterial pressure (MAP), HR, lumbar SNA (LSNA), splanchnic SNA (SSNA), and renal SNA (RSNA) were recorded before and for 2 hours after lateral cerebroventricular leptin or artifici...

The compound S38151 is a nanomolar antagonist that acts at the melanin-concentrating hormone receptor 1 (MCH(1)). S38151 is more stable than its purely peptide counterpart, essentially because of the blockade of its N-terminus. Therefore, its action on various models of obesity was studied. Acute intra-cerebroventricular (i.c.v.) administration of S38151 in wild-type rats counteracted the effec...

The effects of blockade of N-methyl-D-aspartate (NMDA) type glutamate receptors by a non-competitive antagonist (MK-801) on cortical arousal, breathing pattern and ventilatory responses to hypoxia (10% O2 in N2) and hypercapnia (5% CO2 in air) were assessed in anesthetized (urethane) and unanesthetized golden-mantled ground squirrels (Spermophilus lateralis). Intra-cerebroventricular administra...

Pain is a complex process in the central nervous system (CNS). Several factors can alter the pain threshold and insulin is one of them which is produced by the beta cells of pancreas and capable of crossing blood-brain barrier. The aim of this study was to evaluate the effects of intra-cerebroventricular (ICV) injection of insulin on the pain response to formalin in short-term induced diabetic ...

The real time sonographic findings of five neonates with cerebral intraparenchymal hemorrhage are reported. In each case, areas of markedly increased echogenicity corresponded to the site of hemorrhage. Excellent correlation was found between computed tomography (CT) and sonography. Although the sonographic appearance of intraparenchymal hemorrhage is characteristic, it is difficult to separate...

Intraventricular haemorrhage (IVH) is defined as the eruption of blood in the cerebroventricular system and occurs mostly secondary to intracerebral haemorrhage (ICH) in adults. Hydrocephalus is a severe complication of IVH that can serve as an independent predictor of increased mortality. In this mini-review, we focus on the mechanisms of hydrocephalus after adult IVH, including blood-clot blo...