The intraarticular injection of lidocaine immediately before a physiotherapy session may relieve pain during the stretching and mobilization of the affected joint in patients with a frozen shoulder, thus enhancing the treatment effect. To compare the effects of intraarticular injection of lidocaine plus physiotherapy to that of physiotherapy alone in the treatment of a frozen shoulder, a prospe...

Hyaluronic acid (HA) is found in high concentrations in cartilage and synovial fluid, and is an important component of the extracellular matrixes-exerting joint lubrication and buffering actions thanks to its viscoelastic properties. The present study examines the scientific evidence found in the current literature on the usefulness of the intraarticular injection of HA in patients with temporo...

Osteoarthritis (OA) is one of the main causes disability worldwide and caused by progressive degeneration joint tissues, ultimately leading to chronic pain loss function. Intraarticular delivery mesenchymal stromal cells, such as adipose-derived cells (ASCs), being actively investigated due their trophic properties observed in both preclinical clinical studies. However, cell expansion handling ...

Rat ankle joints injected intraarticularly with 5 micrograms of group A streptococcal peptidoglycan-polysaccharide (PG-APS) developed an acute course of arthritis. Recurrence of arthritis was induced in 100% of these joints by intravenous injection of as little as 10 micrograms of Salmonella typhimurium lipopolysaccharide (LPS) 3 wk after intraarticular injection. This reaction was similar in a...

Background: Bone marrow lesions are a radiographic indication of bony pathology closely associated with advanced osteoarthritis the adjacent joint. Injection autologous orthobiologic products, including bone concentrate and platelet-rich plasma, have demonstrated safety efficacy in treating both (via intraarticular injection) intraosseous injection). The relative versus injection orthobiologics...

PURPOSE The aim of the present study was to evaluate the effect of microfracture and intraarticular autologous conditioned plasma (ACP) injection on cartilage regeneration in a focal full-thickness chondral defect model created in the knee joint. METHODS Full-thickness chondral defects of 3 × 6 mm(2) were surgically created in right medial femoral condyles (MFC) of New Zealand rabbits, and th...

Temporomandibular dysfunction (TMD) has been established as a therapeutic challenge in the plastic and maxillofacial clinics. The current treatment recommendations for TMD include resting the jaw, soft diet, and pain medication with nonsteroidal analgesic agents. If conservative and noninvasive techniques do not work, more invasive techniques may be considered. The main goal of this study was t...