The injection of antigen into the anterior chamber (AC, intracameral injection) of a murine eye induces the generation of splenic CD8(+) regulatory T cells (AC-SPL cells) that effect the antigen-specific suppression of a delayed-type hypersensitivity (DTH) reaction. Here we show (i) for the first time that the local antigen-specific suppression of DTH-induced swelling in immunized mice either b...

…………………………………………………………………………………… 8 1 INTRODUCTION …………………………………………………………………………… 10 2 REVIEW OF THE LITERATURE ………………………………………………………… 12 2.1 The Eye ………………………………………………………………………………… 12 2.2 Blood Circulation in the Eye …………………………………………………………… 12 2.2.1 Regulation of Blood Circulation ………………………………………………… 13 2.3 Aqueous Humour Dynamics and Intraocular Pressure ………………………………… 14 2.4 Glaucoma …………………………...

The intraocular effects of substance P (SP) were studied in rabbits by measuring the pupil diameter, intraocular pressure (IOP), and aqueous humor protein concentration. Most of the animals were pretreated with indomethacin to avoid any interaction with prostaglandins. Intracameral injection of 1 to 150 ng of SP caused strong and persistent miosis without appreciably affecting the aqueous humor...

PURPOSE OF REVIEW To summarize current understanding of antibiotic prophylaxis in cataract surgery, with particular emphasis on available evidence and change in practice patterns over the past decade. RECENT FINDINGS Povidone-iodine application prior to cataract surgery remains a universal practice, and is backed by good quality evidence. Subsequent to the results of the European multicenter ...

PURPOSE To study the effect of injection bevacizumab on iris neovascularization (NVI) and angle neovascularization (NVA) and compare its efficacy in terms of visual outcome, NVI, NVA, and intraocular pressure (IOP) control between intracameral, intravitreal, and combined use. MATERIALS AND METHODS This was a prospective study conducted at a tertiary center for patients of neovascular glaucoma...

Descemet membrane detachments are not uncommon following cataract surgery, and large and extensive detachments can have an impressive presentation, with severe corneal edema and marked reduction in visual acuity. Traditional treatment regimens have included observation (with the hopes of spontaneous resolution), anterior chamber injections of air or viscoelastic, transcorneal suturing, and even...

IMPORTANCE Intracameral injection of cefuroxime sodium (1 mg/0.1 mL) has been reported to reduce the risk of endophthalmitis following cataract surgery. In the United States it must be compounded, which is subject to dilution error. We describe a series of 13 eyes that received intracameral injection of cefuroxime sodium, 9 mg/0.1 mL, intraoperatively. OBSERVATIONS On postoperative day 1, 6 o...

INTRODUCTION Posterior capsule rupture causes instant vitreous contamination, resulting in endophthalmitis. However, transfer of intracameral moxifloxacin (MFLX) to the vitreous has not been examined in detail. We investigated vitreous antibiotic concentrations following intracameral MFLX in both ruptured and intact posterior capsular eyes. METHODS Experiment 1: Intraocular lenses were insert...

The effect of intravenous and intracameral ouabain on aqueous humor (AH) formation rates was measured in cats. AH formation rate was determined with continuous, posteroanterior chamber perfusion with an AH-like buffer containing trace quantities of inulin-C. After intravenous injection of 67 fig of ouabain per kilogram, there was a 40 per cent reduction in AH formation rate, while 34 fig per ki...