The ability of medium from gamma-irradiated cells to induce early events in the apoptotic cascade, such as the mobilization of intracellular calcium, loss of mitochondrial membrane potential and increased levels of reactive oxygen species, in unirradiated cells was investigated. Medium from irradiated human keratinocytes was harvested and transferred to unirradiated keratinocytes. Intracellular...

The endogenous reactive oxygen species ("ROS") formation is associated with many pathologic states such as inflammatory diseases, neurodegenerative diseases, brain and heart ischemic injuries, cancer, and aging. The purpose of this study was to investigate the endogenous sources for "ROS" formation in intact isolated rat hepatocytes, in particular, peroxisomal oxidases, monoamine oxidase, xanth...

Background: Basal level of reactive oxygen species (ROS) is essential for sperm acrosomal reaction, hyperactivation, motility, capacitation and fertilization. Ram spermatozoa contain large quantities of polyunsaturated fatty acids in their plasma membranes so are extremely susceptible to ROS induced damage. Materials and Methods: Eight rams (36 ± 5 month of age and with a weight of 64 ± 7 kg) w...

Injectable Hydrogels In article number 2206554, Lin Yu and co-workers develop an injectable thermosensitive hydrogel with inherent long-acting NO-releasing capacity. The system loaded β-lapachone CuCys nanoparticles can synchronously boost intracellular reactive oxygen species nitrogen levels, thereby synergistically enhancing the anti-tumor efficacy. This is suitable as a platform for extendin...

in assisted reproduction techniques (art) settings, reactive oxygen species (ros) can be produced from endogenous and exogenous sources during in vitro manipulation. endogenous sources of ros include gametes and embryo, whereas exogenous sources are oxygen tension, light exposure, culture media, and the nature of some protocols, such as centrifugation or cryopreservation. elevated ros productio...