Degeneration of cerebellar cortex is one of the principal features of hereditary ataxias linked to expansion of CAG repeat. In an attempt to clarify possible correlation between neuronal depletion and neuronal intranuclear inclusions, both triggered by the pathological expansion of CAG repeat, cerebellar sections from SCA1, SCA2, SCA3, and DRPLA cases were immunostained with anti-ubiquitin or a...

Expansion of a polyglutamine repeat in huntingtin causes Huntington's disease (HD). Although full-length huntingtin is predominantly distributed in the cytoplasm, N-terminal fragments of huntingtin with expanded polyglutamine tracts are able to accumulate in the nucleus and kill neurons through apoptotic pathways. Transgenic mice expressing N-terminal mutant huntingtin show intranuclear hunting...

Mongolian gerbils fed diets containing lead acetate maintained body weight comparable to gerbils fed the same diet without added lead. Intranuclear lead inclusion bodies in epithelial cells of the proximal convoluted tubules of the kidney were first observed at 4 weeks, and increased in number to about 50 per high power field at 12 weeks. At this time, a corticomedullary area of empty-appearing...

The kidneys from six immunodeficient mice examined by Cerberus Sciences and the Animal Resources Centre, displayed karyomegaly with pale eosinophilic, intranuclear inclusions upon histopathological examination. Electron microscopy performed on kidney tissue from 5/6 mice demonstrated margination of the chromatin in large nuclei. Laboratory tests were used to detect nucleic acid of papillomaviru...

The association of RNA polymerase III (Pol III)-transcribed genes with nucleoli seems to be an evolutionarily conserved property of the spatial organization of eukaryotic genomes. However, recent studies of global chromosome architecture in budding yeast have challenged this view. We used live-cell imaging to determine the intranuclear positions of 13 Pol III-transcribed genes. The frequency of...

The effects of amiloride, a reported inhibitor of serum-stim ulated sodium influx, were tested on tumor growth, tumor cell proliferation, and intracellular element content of cancer cells in vivo. We have shown previously that cancer cells have high intranuclear levels of sodium compared to those of their normal counterpart cells and have postulated that such a high level of sodium may be invol...

The objective of our study was to explain the histopathological changes of monodon baculovirus (MBV) in hepatopancreas and midgut tissues of the cultured Penaeus vannamei. Five-hundred and forty juvenile of P. vannamei with average size of 7.99±0.54 g and 3600 post larvae 10-15 were distributed to 18 glass aquariums (50×50×60cm) with 100L well aerated water per each aquarium as water borne MBV ...

the objective of our study was to explain the histopathological changes of monodon baculovirus (mbv) in hepatopancreas and midgut tissues of the cultured penaeus vannamei. five-hundred and forty juvenile of p. vannamei with average size of 7.99±0.54 g and 3600 post larvae 10-15 were distributed to 18 glass aquariums (50×50×60cm) with 100l well aerated water per each aquarium as water borne mbv ...

Pedestrian detection is among the most safety-critical features of driver assistance systems for autonomous vehicles. One complex challenges that partial occlusion, where a target object only partially available to sensor due obstruction by another foreground object. A number current pedestrian benchmarks provide annotation occlusion assess algorithm performance in these scenarios, however each...