Background and Aims: The Inclusion Body Hepatitis disease (IBH) is one of the prevalent illnesses in our country these days and reported from different regions of Iran. In addition to its fatality, the importance of this disease is disturbing the vaccination program in poultry, especially broiler chickens, against other diseases like infectious bursal disease (IBD) and Newcastle disease (ND). T...

Intranuclear inclusions were found in 75 per cent of young mice suffering from a spontaneous diarrheal disease. They were confined to the epithelial cells of the small intestine, and to the intestinal and mesenteric lymphadenoid tissue. They were seen only between the 10th and 15th days after birth, in apparently healthy control mice of the same age group, they were found in only two of thirty-...

A progressive wart-like syndrome in both captive and wild populations of the Western barred bandicoot (WBB) is hindering conservation efforts to prevent the extinction of this endangered marsupial. In this study, 42 WBBs exhibiting the papillomatosis and carcinomatosis syndrome were examined. The disease was characterized by multicentric proliferative lesions involving cutaneous and mucosal sur...

Intranuclear inclusionsof cytomegalovirus infections were first noticed in 1881 by Ribbert5 who thought they represented protozoa, He saw large cells in sections of the kidney of a luetic stillborn and in the parotid gland of children.5 In 1907 Lòwenstein6 found such cells in the parotid glands of 4 out of 30 infants. These appear to be the first descriptions of typical cytomegalic cells with i...

Replication of measles virus in HeLa cells was examined by electron microscopy with ultrathin sectioning and phosphotungstic acid negative staining methods. The cytoplasmic inclusion bodies consisted of masses of helical nucleocapsid which was similar in structure to the nucleocapsid found in measles virions. The cytoplasmic helical nucleocapsid appeared to align near the HeLa cell membrane, an...

It is well established that many viruses produce inclusion bodies in the nucleus or cytoplasm of an affected cell, and that the morphological appearance of such inclusions may be pathognomonic of a particular infection (Pinkerton, 1950). Similar bodies may also result from the toxic action of certain heavy metals (Lee, 1933; Blackman, 1936; Olitsky and Harford, 1937). They are occasionally foun...

High-dose lead exposure in rodents has been shown to produce pathognomonic lead intranuclear inclusion bodies and to result in an increased incidence of renal adenocarcinomas. Studies from this laboratory and others have demonstrated the presence of high-affinity renal lead-binding proteins in rat kidneys which act as tissue sinks for lead at low dose levels. Cell-free nuclear translocation stu...

We report idiopathic intranuclear inclusion bodies in the renal tubular epithelia of two cases of among the 960 Japanese quail (Coturnix coturnix japonica) in the course of the acute oral toxicity and dietary toxicity test. Basophilic inclusion bodies were seen only in the nuclei of renal tubular epithelia. We could not classify our case into any adenovirus infection by clinical signs and lesio...