Introduction: Wilms tumor is the most common kidney cancer in children, but Wilms's tumors that extend by direct intravascular spread into right side of heart are rare and at this stage, they require cardiac surgeons’ intervention. Case Presentation: The patient was a 2-year-old girl who hospitalized due to fever abdominal pain had started 2 weeks before admission. Patient’s full exams revealed...

Wilms tumor (WT) is the most common renal malignancy seen in pediatric patients. Although lungs are site of metastasis Wilms tumor, non-malignant pleural effusion has been infrequently reported. Here, we report a case an eleven-year-old female who presented with abdominal mass and progressive breathlessness. On further evaluation, she was found to have right-sided ipsilateral massive eff...

Teratoid Wilms tumor is a rare variant of Wilms tumor composed predominantly of well-differentiated epithelial and/or mesenchymal heterologous elements. Like the classical Wilms tumor, this variant may also occur as a renal mass or may be found in extra renal locations. This tumor may be treated effectively by surgical resection; however, it generally fails to respond to chemotherapy. A review ...

Wilms' tumor is one of the most frequent malignant neoplasms in childhood. Advances in treatment modalities such as the combination of chemoradiation therapy with surgery have enhanced overall survival. However, recurrence of Wilms' tumor is still a problem. In this case, a 28-year-old female had experienced intermittent abdominal pain, and the computed tomography scan showed a huge pelvic mass...

Wilms' tumor has served as an example of Knudson's two-hit hypothesis of recessive tumor genes, but the genetics has proven to be surprisingly complex. WT1, a tumor suppressor gene on 11p13, is mutated in only a small fraction of Wilms' tumors, and a second chromosomal region, 11p15, harbors a second Wilms' tumor gene also involved in other cancers. In addition, loss of genomic imprinting, or p...

OBJECTIVE The current study was undertaken to explore the clinical and prognostic value of phosphatase of regenerating liver-3 (PRL-3) expression in Wilms' tumor. METHODS Seventy-six patients with Wilms' tumor in Qilu Hospital from January 2003 to July 2009 were enrolled in the study. Protein expression level of PRL-3 was examined by immunohistochemical staining, and the correlation between P...

increment. it is categorized based on genetic aberrations. some of these genetic disorders can determine minimal residual diseases (mrd) and prognosis of aml patients. wilms tumor (wt1) over expression is found in aml patients. the aim of this study was to determine the frequency of wt1 over expression in aml pediatric cases in north -east of iran. materials and methods: this retrospective stud...

The incidence of horseshoe kidney is about 1 in 400 cases. The presence of Wilms' tumor with a horseshoe kidney is unusual, and the occurrence of Wilms' tumor in a horseshoe kidney is estimated at 0.4 to 0.9% of all Wilms' tumors. We report the case of a 5-year-old boy who presented with a stage IV Wilms' tumor in a horseshoe kidney. The patient was treated with preoperative chemotherapy follow...