PURPOSE To identify retinal genes and their relevant expression pathways affected by intravitreal injections of dexamethasone (Dex) and triamcinolone acetonide (TAA) in mice at clinically relevant time points for patient care. METHODS Differential gene expressions of over 34,000 well-characterized mouse genes, in the retinas of 6-week-old C57BL/6J mice, were analyzed after intravitreal steroi...

The eye is probably the most attractive site of the body for treatment using locally delivered therapeutic agents. An ideal indication for such an approach is noninfectious posterior uveitis. Since intraocular structures of the posterior segment are difficult to reach and are otherwise accessible only by systemic treatment, current interest is focused on the pros and cons of intravitreal drug d...

PURPOSE To report the frequency and clinical features of sterile inflammation after intravitreal aflibercept injection in a Korean population. METHODS A single-center, retrospective study was performed in patients who received intravitreal aflibercept from July 2013 through January 2015. RESULTS A total of four cases of post-injection sterile inflammation were identified from 723 aflibercep...

In the past, a surgeon working on the Fuchs’ eye would use intensive topical steroid for the postoperative weeks. However, in the last decade a shift to the fore of intraocular drugs has made these agents a valuable adjunct to cataract surgery. When removing cataract from eyes with noninfectious uveitis I routinely employ a dose of intravitreal steroid. This approach results in a settled course...

Aim: Several ocular and systemic complications have been reported after the bevacizumab intravitreal injection. This study aims at reporting the main indications for the bevacizumab intravitreal injection in our center, the intravitreal injection method in this study, and the incidence of the post-injection complication, such as endophthalmitis.Methods: This study is a retrospective review of t...

Diabetic macular edema is the most common cause of visual impairment in patients with diabetes mellitus. The pathogenesis of macular edema is complex and multifactorial. For many years, laser photocoagulation has been considered the standard therapy for the treatment of diabetic macular edema; however, few patients achieve significant improvements in visual acuity. Today the intravitreal admini...

BACKGROUND According to recent studies, the newest strategy for the treatment of exudative age-related macular degeneration is to combine anti-VEGF agents with non-steroid anti-inflammatory drugs (NSAIDs) such as nepafenac and bromfenac to decrease the frequency of intravitreal injections. Since most research has focused on ranibizumab, the aim of this study is to evaluate whether an alternativ...

INTRODUCTION The causative organism and treatment outcomes of post operative endophthalmitis may vary depending on several factors. OBJECTIVE To find out the causative organisms and visual outcome after an outbreak of post-operative endophthalmitis. MATERIALS AND METHODS An interventional prospective series of cases of clinically suspected endophthalmitis was studied. Eleven patients who pr...

Background: Cystoid Macular Edema (CME) is one of the most common and sight threatening complications of uveitis. Intravitreal injection of corticosteroids and anti-VEGF antibody are two routine options for treatment. Objective: To compare the effects of intravitreal injections of Bevacizumab and Triamcinolone Acetonide for the treatment of persistent macular edema in non-infectious uveitis. Me...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background : diabetic macular edema (dme) is the most common cause of reduced vision in diabetic patients. with regards to its prevalence and its severe morbidity, attention to new methods of treatment like anti-vascular endothelial growth factor (vegf) therapy is of great importance. therefore, this study aimed to evaluat...