BACKGROUND A previous study explored factors discriminating colonization and true infection among non-transplant, non-neutropenic patients with repeated Aspergillus spp. isolation from lower respiratory samples. The present study explored the evolution of patients with Aspergillus colonization in that study to determine the percentage of cases progressing to aspergillosis and time to developmen...

Communications to the Editor 3 Burnie JP. Antigen detection in invasive aspergillosis. J Immunol Methods 1991; 143:187-95 4 Van Cutsenss J, Meulemans L, Van Gerven F, Stynsen D. Detection of circulating gahactomannan by Pastorex Aspergillus in experimental invasive aspergillosis. Mycoses 1990; 33:61-9 5 Hashiguchi K, Wada H, Yamada 0, Yawata Y, Yoshida K, Okimoto N, et al. A case of chronic mye...

Wegener's granulomatosis usually presents with clinical features of systemic vasculitis affecting lung, upper respiratory tract, kidney and even a nervous system. Yet, invasive pulmonary aspergillosis is characterised by invasion of blood vessels in the lungs, but the infection often spreads to kidneys, skin and central nervous system. We report a case of a 46-year-old male patient with no prio...

Aspergillus niger is usually considered to be a low virulence fungus, not commonly reported to cause invasive infections. Invasive pulmonary aspergillosis due to Aspergillus niger was diagnosed in a 43-year-old woman following bilateral lung transplantation. Intravenous voriconazole failed to control progression of the disease. Despite salvage therapy with a combination of voriconazole and casp...

While the epidemiology and clinical differences of various Candida spp. has been relatively well-identified, data regarding invasive aspergillosis (IA) caused by different Aspergillus spp. are insufficient.We aimed to determine the epidemiology of culture-positive invasive pulmonary aspergillosis (IPA) and to compare the characteristics and outcomes of Aspergillus fumigatus IPA with those of no...

In invasive pulmonary aspergillosis, direct invasion and occlusion of pulmonary vasculature by Aspergillus hyphae causes tissue hypoxia, which is enhanced by secreted fungal metabolites that downregulate compensatory angiogenic signaling pathways. We assessed the effects of basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) on survival rates, fungal burden, and ...

conclusions hrct is helpful in the diagnosis of invasive pulmonary aspergillosis in patients with lung-heart transplant. methods we reviewed the data of lung-heart transplant recipients within a 5 year period at our center. the inclusion criterion was confirmed invasive pulmonary aspergillosis. demographic, clinical, radiologic and laboratory characteristics of the patients were retrieved from ...

Pulmonary involvement with Aspergillus fumigatus is varied and largely dependent on the patient's underlying pulmonary and immune status. Hypersensitivity reactions from inhalation of spores can cause acute allergic alveolitis, and bronchial colonization can cause allergic bronchopulmonary aspergillosis (ABPA). The latter is found mainly in patients with asthma or cystic fibrosis. Mycetomas dev...