Pumiliotoxin B (PTX-B), an alkaloid that has cardiotonic and myotonic activity, increases sodium influx in guinea pig cerebral cortical synaptoneurosomes. In the presence of scorpion venom (Leiurus) or purified alpha-scorpion toxin, the PTX-B-induced sodium influx is enhanced severalfold. PTX-B alone has no effect on sodium flux in N18 neuroblastoma cells but, in the presence of alpha-scorpion ...

In Algeria scorpion envenomation represents a real public health problem with a population at risk of scorpion stings estimated at 68% of the national population. A total of 903, 461 scorpion sting cases and 1996 deaths were recorded by health services between 1991 and 2012. The physical-geographic and climate conditions make the province of Naama a conducive environment for scorpion species an...

Introduction Accidental scorpion sting is a serious health issue of poor communities in tropical and subtropical areas throughout the world. Out of 1500 scorpion species distributed throughout the world, only 50 scorpion species have been proved lethal to human [1]. The symptoms of scorpion envenomation depend on species, age, venom composition and the victim’s physiological response. Scorpion ...

OBJECTIVE To study the efficacy of anti-scorpion venom plus prazocin. METHODS Comparison of clinical features, outcome and duration of stay between children receiving anti-scorpion venom plus prazocin or prazocin alone for management of red scorpion envenomation. RESULTS Requirement for dopamine and requirement and duration of dobutamine therapy were significantly less in patients received ...

Although many studies concerning the sensitivity mechanism of scorpion toxin-potassium channel interactions have been reported, few have explored the biochemical insensitivity mechanisms of potassium channel receptors toward natural scorpion toxin peptides, such as the KCNQ1 channel. Here, by sequence alignment analyses of the human KCNQ1 channel and scorpion potassium channel MmKv2, which is c...

1 Rahav G, Weiss AT. Scorpion sting-induced pulmonary edema: scintigraphic evidence of cardiac dysfunction. Chest 1990; 97:1478-80 2 Gueron M. Actinomyces me rii breast abscess [letterl. Am J Med 1988; 84:369 3 Sofer S, Gueron M. Respiratory failure in children following envenomation by the scorpion L, iurus quinquestriatus: hemodynamic and neurological aspects. Toxicon 1988; 26:931-39 4 Gueron...

Photoreactive derivatives of alpha- and beta-scorpion toxins have been used to analyze the subunit composition of Na+ channels in rat brain. In synaptosomes, both types of toxins preferentially labeled (greater than 85%) a component of 34,000 Da and, at a lower level, another component of 300,000 Da. Reduction of disulfide bridges shifted this latter band from 300,000 Da to 272,000 Da but did n...

an updated checklist of the scorpion fauna of iran, as well as a brief history of taxonomic research on scorpions of iran is presented. the checklist is based on records of scorpion species whose presence has been confirmed in iran through field expeditions, examination of scorpion collections, literature review, and personal communications from researchers. the scorpion fauna consists of 51 sp...

Death due to scorpion envenoming syndrome is a common event in tropical and subtropical countries. Severe scorpion envenoming causes autonomic storm, massive release of catecholamines, counter-regulatory hormones, suppressed insulin/hyperinsulinemia, acute myocarditis, hyperglycemia, increased free fatty Acid levels, acute pancreatitis, disseminated intra-vascular coagulation, acute pulmonary o...

Scorpion mono[‘2sIJiodotoxin binds to a single class of receptor sites associated with voltage-sensitive sodium channels in synaptic nerve ending particles (synaptosomes) with a KD of approximately 3 11~. Scorpion toxin binding is inhibited by depolarization of the synaptosomes with K+ or gramicidin or by lysis of the synaptosomes. Scorpion toxin binding is enhanced by batrachotoxin, veratridin...