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Agarose electrophoresis (Isopal, Beckman) and an immunoradiometric assay (IRMA) involving specific monoclonal antibodies (Ostase, Hybritech), two methods for the quantification of serum bone alkaline phosphatase (ALP, EC 3.1.3.1), a marker of osteoblastic activity, were compared in 293 patients: 79 with end-stage renal failure treated with hemodialysis and 214 with malignant disease. Overall co...

The impact of the adoption of the new biosynthetic growth hormone (GH) WHO International Reference Preparation (IRP 88/624), and the recommendation to report results in microgram/L instead of mU/L, is described. Conversion factors were determined by comparing both the linear and nonlinear relations of the GH values. The Pharmacia polyclonal IRMA (p-IRMA) and the DELFIA monoclonal time-resolved ...

Image retrieval in medical applications (IRMA) requires the cooperation of experts in the eld of medicine, image analysis, feature analysis and systems engineering. A distributed developing platform was implemented to support the progress of the IRMA{system. As the concept for this system strictly separates the steps for medical image retrieval, its components can be developed separately by wor...

MOTIVATION Investigating the relation between the structure and behavior of complex biological networks often involves posing the question if the hypothesized structure of a regulatory network is consistent with the observed behavior, or if a proposed structure can generate a desired behavior. RESULTS The above questions can be cast into a parameter search problem for qualitative models of re...

This paper presents a component of the ongoing research project Integrated Real-time Mobility Assistant (IRMA). The component's name is Compensation Engine. IRMA is a software system that targets the personal mobility in a near future scenario, based on green, shared and public transports. IRMA handles end-to-end itineraries that may involve multiple transport systems, and supports the use...

The role of Dbf4-dependent protein kinase in DNA polymerase ζ-dependent mutagenesis in S. cerevisiae Luis N. Brandão*, Rebecca Ferguson*, Irma Santoro§, Sue Jinks-Robertson§† and Robert A. Sclafani* * Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO 80045 §Department of Biology, Emory University, Atlanta, GA †Department of Molecular Geneti...

Serum bone alkaline phosphatase (ALP; EC 3.1.3.1) was measured with a wheat germ agglutinin (WGA) precipitation assay and with a new IRMA in a group of healthy elderly women. Both assays were correlated with serum total ALP activity and with osteocalcin. The two bone ALP assays have comparable within- and between-run imprecisions (WGA assay within-run CVs 2.6-5.4% and between-run, 4.0-5.1%; IRM...

Elevated circulating chromogranin A (CgA) levels are found in neuroendocrine tumors (NETs), but the diagnostic usefulness of this marker is still debatable. To assess the role of CgA for the diagnosis of gastroenteropancreatic (GEP) NETs and the identification of metastatic patients, an Italian multicenter observational study has been performed. CgA was evaluated in 202 GEP NET patients by IRMA...