Abstract Background Iron overload is the main transfusion related side effects in patients with transfusion dependent hemoglobinopathies. Severe iron deposition in tissues leads to organ dysfunction. Many organs can be affected such as heart, liver, and endocrine organs. Cardiac failure and liver fibrosis are the consequent of Iron overload in transfusion dependent hemoglobinopathy. Magne...

The synthesis and characterization of novel tetranuclear and octanuclear iron(III) complexes with structures based on a nearly square arrangement of four iron ions are reported. Reaction of ferric nitrate, sodium acetate, and the unsymmetrical binucleating ligand HBMDP, where HBMDP is N,N,N'-tris((N-methyl)-2-benzimidazolylmethyl)-N'-methyl-1,3-diamino-2-propanol, in acetone/water yields the te...

background: tissue iron deposition may disturb functions of the organs. in many diseases like thalassemia, the patients suffer from iron deposition in kidney and heart tissues. deferoxamine (df) is a synthetic iron chelator and silymarin (sm) is an antioxidant and also a candidate for iron chelating. this study was designed to investigate the effect of df and sm combination against kidney and h...

A colorimetric assay was developed for studying the kinetics of iron oxidation with whole cells of the chemoautotroph, Ferrobacillus ferrooxidans. The assay was more advantageous than the conventional method of Warburg manometry because of its simplicity, rapidity, and the small amount of cells required. The assay measured Fe(3+) as a chloride complex which absorbs at 410 nm. Kinetic analysis s...

Commercial elemental iron powders (electrolytic and reduced iron), as well as heme iron supplements, were tested for efficacy in improving the iron status of women. In a randomized, double-blind trial, 51 women with moderate to low iron stores received daily for 12 wk: 1) placebo, 2) 5 mg iron as heme iron or 50 mg iron as 3) electrolytic iron, 4) reduced iron, or 5) FeSO(4). Treatments were pr...

kuh-e-faryadoon and kouli kosh iron deposits are hosted by regional metamorphic rocks of sanandaj-sirjan zone around deh-bid area. plugs and domes of acid rocks protrude these metamorphic rocks. a mylonitization event is super imposed on acid rock and metamorphic complexes. field, petrological and geochemical studies have shown that (1) iron mineralization have occurred during mylonitization in...

2:00 2:30 Maarten Merkx – Multicolor intracellular zinc imaging. 2:30 3:00 Artur Krezel – Zinc ion probes for investigating transient zinc protein interactions 3:00 3:30 Wolfgang Maret – Chemical biology of probes for cellular metallotransmitters 3:30 4:00 Tea 4:00 4:30 Bob Hider – Iron sensitive fluorescent probes: monitoring the intracellular labile iron pool. 4:30 5:00 Lukas Kuhn – Iron regu...