The incidence rate of liver cancer is increasing year by globally. Liver transplantation has become one the therapeutic methods for patients with cancer. In past, ischemia-reperfusion injury (IRI) was unavoidable in transplantation, compromising recipient and graft survival. At same time, imbalance between supply demand organs limits use Recently, advances have been made machine perfusion techn...

BACKGROUND Remote ischemic perconditioning (RIPerC), remote ischemic postconditioning (RIPostC), and remote ischemic perconditioning + postconditioning (RIPerC + RIPostC) protect against renal ischemia reperfusion injury (IRI). However, the most beneficial approach among these is not known. AIMS To compare the protective effects and study the mechanisms of three different remote ischemic cond...

Ischemia/reperfusion injury (IRI) is caused by a sudden temporary impairment of the blood flow to the particular organ. IRI usually is associated with a robust inflammatory and oxidative stress response to hypoxia and reperfusion which disturbs the organ function. Renal IR induced acute kidney injury (AKI) contributes to high morbidity and mortality rate in a wide range of injuries. Although th...

Mesenchymal stem cells (MSCs) are a potential therapeutic tool for preventing the progression of acute kidney injury (AKI) to chronic disease (CKD). Herein, we investigated localization and maintenance engrafted human bone marrow-derived MSCs in rats subjected renal ischemia-reperfusion (IRI) compared effectiveness two intravascular injection routes via artery or inferior vena cava. Renal was m...

Background and AimsDonors with fatty livers are considered to address the shortage of for transplantation, but those particularly sensitive ischemia-reperfusion injury (IRI), an increased incidence graft failure is observed. Kupffer cells account 20–35% liver nonparenchymal cells, have been shown participate in process IRI inflammatory reactions hepatic steatosis. NOD-like receptor thermal prot...

Ischemia reperfusion injury (IRI) leads to significant tissue damage in liver surgery. Polyethylene glycols (PEGs) are water soluble nontoxic polymers that have proved their effectiveness against IRI. The objective of our study was to investigate the potential protective effects of intravenous administration of a high molecular weight PEG of 35 kDa (PEG 35) in steatotic livers subjected to cold...

Regulatory T cells (Tregs) suppress excessive immune responses and are potential therapeutic targets in autoimmune disease and organ transplantation rejection. However, their role in renal ischemia-reperfusion injury (IRI) is unclear. Levels of Tregs and expression of CXCR3 in Tregs were analyzed to investigate their function in the early phase of renal IRI. Mice were randomly divided into Sham...

Ischemia-reperfusion injury (IRI) is the major cause of acute kidney injury. Remote ischemic conditioning (rIC) performed as brief intermittent sub-lethal ischemia and reperfusion episodes in a distant organ may protect the kidney against IRI. Here we investigated the renal effects of rIC applied either prior to (remote ischemic preconditioning; rIPC) or during (remote ischemic perconditioning;...

Diminishing ischemia-reperfusion injury (IRI) by improving kidney preservation techniques offers great beneficial value for transplant recipients. Mitochondria play an important role in the pathogenesis of IRI and are therefore interesting targets pharmacological interventions. Hypothermic machine perfusion (HMP), as a strategy, possibility to provide mitochondrial–targeted therapies. This stud...

Correspondence: Mohamed S. A. Mohamed, MBBCh, MSc, MD. Thoracic Transplantation Department, University Clinic Essen, Germany, Hufeland Straße 55. D-45147 Essen. Email:[email protected] Ischemic preconditioning is a technique where prior application of repeated short cycles of ischemia and reperfusion would be able to attenuate the severity of the subsequent ischemic reperfusion injur...