BACKGROUND Radial artery (RA) aortocoronary bypass grafts anastomosed to a branch of the circumflex coronary artery have significantly better patency rates than saphenous vein (SV) grafts at 5 years, but the physiological characteristics and mechanisms involved are not clearly defined. We compared RA and SV graft vasomotor and flow responses to endothelium-dependent and -independent stimuli 5 y...

The present study evaluated the beneficial effect of aqueous extract of garlic (Allium sativum L.; 100mg/kg/day) on the alterations in vascular reactivity of streptozotocin-diabetic rats. After 8 weeks of treatment, thoracic aortic rings of rats were mounted in organ baths and contractile responses to phenylephrine and relaxant responses to acetylcholine and isosorbide dinitrate were assessed. ...

AIMS This study aims to visualize ultrasonically deformation of atherosclerotic plaques in human coronary arteries during vasoconstriction and vasodilatation. METHODS AND RESULTS Intravascular ultrasound detected occult atherosclerosis in angiographically normal coronary arteries of eight patients with chest pain at rest. During the acetylcholine provocative test, intravascular ultrasound mon...

berg A, et al. Diagnosis and management of out-of-hospital cardiac arrest secondary to coronary artery spasm. Resuscitation. 2003;58:145-52. 2. Karch SB. Coronary artery spasm induced by intravenous epi-nephrine overdose. High dose nitroglycerin treatment in a patient with cardiac arrest: a case report. A. Recurrent catecholamine-induced coronary vasospam treated by intracoronary injection of i...

Dermal nitrate preparations are claimed to be useful in the treatment of angina, as their slow absorption by-passing the liver leads to a sustained action. Ten patients with angina were exercised on a treadmill after dermal application of 16.64 mg glyceryl trinitrate or 100 mg isosorbide dinitrate or placebo. Exercise duration was significantly increased at one and three hours for both nitrate ...

A double-blind study of the effects of isosorbide dinitrate, 10 mg given orally four times a day, propranolol, 40 mg four times a day, and the combination of these two drugs was performed on 21 patients with angina pectoris. Each patient received placebo, isosorbide, propranolol, and the combination of the two drugs for 1 month each in a random sequence over 4 months. The number of anginal pain...

BACKGROUND Nitrates and furosemide, commonly administered in the treatment of pulmonary oedema, have not been compared in a prospective clinical trial. We compared the efficacy and safety of these drugs in a randomised trial of patients with severe pulmonary oedema and oxygen saturation below 90%. METHODS Patients presenting to mobile emergency units with signs of congestive heart failure wer...

angiotensin ii is a major endocrine hormone that affects directly both vascular smooth muscle and endothelial cells. since vascular reactivity to angiotensin ii changes in more physiological and pathophysiological conditions, the present study was performed to investigate the effect of intraperitoneal administration of angiotensin-converting enzyme inhibitor and captopril (30 and 50 mg kg-1, on...

The article studies the domestic market of vasodilators for cardiac diseases in Belarus by analyzing and comparing secondary marketing information. structure depending on manufacturing country was studied. It established that medicines containing isosorbide mononitrate/dinitrate have greatest number indications to use least side effects. dynamics changing sales group period 2010-2018 is present...