Two selective stability-indicating HPLC methods are described for determination of rabeprazole sodium (RZ)-mosapride citrate (MR) and RZ-itopride hydrochloride (IO) mixtures in the presence of their ICH-stress formed degradation products. Separations were achieved on X-Bridge C18 column using two mobile phases: the first for RZ-MR mixture consisted of acetonitrile: 0.025 M KH2PO4 solution: TEA ...

One of the most common pathologies in structure digestive diseases is gastroesophageal reflux disease (GERD), which associated with low life quality patients, while insufficient control — an increased risk Barrett's esophagus and, as a consequence, adenocarcinoma. In accordance relevant consensus papers, particular, Lyon Consensus, key factor GERD pathogenesis persistent disorder upper tract mo...

The self-aggregation of itopride HCl in water at different temperatures has been studied. Critical aggregation concentrations (CAC) and the degree of ionization (α) have been determined by conductivity measurements over the temperature range from 293.15 – 318.15 K. The thermodynamics parameters of self-aggregation; the standard Gibbs energy change G°m, the standard enthalpy change, ∆ H°m, and ...

Acetylcholinesterase (AChE) inhibitors stimulate gastrointestinal (GI) motility and are potential treatments of conditions associated with inadequate GI motility. The ability of itopride to facilitate neuronally (predominantly cholinergic) mediated contractions of rat isolated stomach, evoked by electrical field stimulation (EFS), has been compared with other cholinesterase inhibitors and with ...

Purpose. To present the materials of Expert Council, which was held on April 22, 2023 in Moscow and dedicated to modern approaches management patients with unexplored dyspepsia, as well choice optimal Helicobacter pylori eradication therapy scheme Russian Federation. The main provisions resolution. An initial patient recent dyspeptic symptoms who has not taken drugs that can cause gastric damag...