Intravenous and intra-arterial thrombolysis (IVT and IAT, respectively) are the two major therapeutic options for management of acute ischemic stroke (AIS). However, the FDA has only approved IVT for management of AIS, when the patient presents within 0-4.5 hours of AIS onset. This recommendation was based on numerous randomized controlled trials (RCT) which, when analyzed together, showed a ne...

BACKGROUND symptomatic intracerebral haemorrhage (ICH) is a major concern of intravenous thrombolysis (IVT) for ischaemic stroke. Asians are considered more vulnerable to ICH than non-Asians. Reports on safety of IVT for Asian octogenarians and nonagenarians are limited. AIMS the aims of our study were to compare the safety of IVT between octogenarians and nonagenarians and between Asian and ...

The purpose of this study was to assess the effects of transforming growth factor beta (TGF-β) inhibitor peptides (P17 & P144) on early laser-induced choroidal neovascularization (LI-CNV) lesions in rats, two weeks after laser CNV induction. Seventy-one Long Evans rats underwent diode laser application in an established LI-CNV model. Baseline fluorescein angiography (FA) was performed 14 days f...

Letter by Kamtchum-Tatuene et al Regarding Article, “Mechanical Thrombectomy Improves Functional Outcomes Independent of Pretreatment With Intravenous Thrombolysis” To the Editor: We read with great interest the recent article by Tsivgoulis et al demonstrating that endovascular thrombectomy (ET) improves the functional outcome of patients with emergent largevessel occlusion (ELVO) independent o...

INTRODUCTION We investigated whether thrombus length measured in Computed Tomography Angiography (CTA) is predictive of the success rate of intravenous thrombolysis (IVT) in acute basilar occlusion and whether recanalization can be achieved by additional mechanical endovascular thrombectomy. METHODS In 51 patients with acute basilar thrombosis thrombus length was measured on CTA images before...

INTRODUCTION Based on data from the Baden-Wuerttemberg stroke registry, we aimed to explore the diurnal variation of acute ischemic stroke (IS) care delivery. MATERIALS AND METHODS 92,530 IS patients were included, of whom 37,471 (40%) presented within an onset-to-door time ≤4.5 h. Daytime was stratified in 3-h time intervals and working vs. non-working hours. Stroke onset and hospital admiss...

BACKGROUND AND PURPOSE IVT administered in acute ischemic stroke provides low recanalization rates in proximal intracranial occlusions, with consequently poor clinical outcome. The safety and efficacy of an IES by using mechanical thrombectomy after IVT failure were assessed in acute MCA occlusions. MATERIALS AND METHODS Patients presenting with acute MCA occlusion within 4.5 hours with an NI...

BACKGROUND Reperfusion following ischemic stroke can be attained by either intravenous thrombolysis (IVT) or intra-arterial thrombolysis (IAT). Only a limited number of randomized prospective studies have compared the efficacy and safety of IVT and IAT. This meta-analysis investigated possible clinical benefits of IAT relative to IVT in patients with acute ischemic stroke. METHODS We searched...

Purpose: To investigate the efficacy of the posterior subtenon (SBT) capsule injection of TA as compared to intravitreal (IVT) injection of Triamcinolone Acetonide (TA) for the management of cystoid diabetic macular edema in pseudophakic patients. Methods: This prospective randomized comparative study included 100 pseudophakic eyes with cystoid macular edema. They were divided into two equal gr...

BACKGROUND Understanding the factors that influence the hospital length of stay (LOS) for patients with stroke will help in discharge planning and stroke unit management. We explored how intravenous thrombolysis (IVT) affects LOS in an acute-care hospital setting. METHODS We analyzed adult patients with ischemic stroke who presented within 48 h of onset from a hospital-based stroke registry. ...