Sporadic Creutzfeldt-Jacob disease (CJD) is a rare neurodegenerative, prion disease characterized by rapidly progressive dementia, visual disturbances, myoclonus and extrapyramidal and pyramidal involvement. An 80-year-old woman presented with progressive dementia and visual and auditory hallucinations over a two-month period. Neurological examination revealed cognitive impairment and right hem...

To estimate the effect of the variability of prion disease onset on primary bovine spongiform encephalopathy transmission to humans, we studied 6 cynomolgus macaques. The preclinical incubation period was significantly prolonged in 2 animals, implying that onset of variant Creutzfeldt-Jacob disease in humans could be more diverse than previously expected.

Case report We describe the case of an elderly female patient who presented with psychotic symptoms in the absence of neurological signs and symptoms, and after systematic diagnostic evaluation eventually turned out to be a sporadic CJD case. Conclusions In clinical practice CJD should not be neglected as differential diagnosis in elderly patients with negative psychiatric history referring to ...