among the numerous nanosized drug delivery systems currently under investigation, carbon nanotubes (cnts), regardless of being single or multiple-walled, offer several advantages and are considered as promising candidates for drug targeting. despite the valuable potentials of cnts in drug delivery, their toxicity still remains an important issue. after the pegylation of single-walled cnts (swcn...

objective: it is a firm belief that blood transfusion is life-saving in many situations, but at the same time transfusion complications could be life-threatening. the possible effects of blood transfusion related immunomodulatory (trim) and its related mechanisms is one of the important debatable subjects in the field of blood transfusion medicine. one of the mechanisms through which transfus...

     Among the numerous nanosized drug delivery systems currently under investigation, carbon nanotubes (CNTs), regardless of being single or multiple-walled, offer several advantages and are considered as promising candidates for drug targeting. Despite the valuable potentials of CNTs in drug delivery, their toxicity still remains an important issue. After the PEGylation of single-walled CNTs ...

     Among the numerous nanosized drug delivery systems currently under investigation, carbon nanotubes (CNTs), regardless of being single or multiple-walled, offer several advantages and are considered as promising candidates for drug targeting. Despite the valuable potentials of CNTs in drug delivery, their toxicity still remains an important issue. After the PEGylation of single-walled CNTs ...

The inhibitory effect of microRNA (miR)-325 in multiple different types cancer cell has been identified; however, its biological function T acute lymphoblastic leukemia (T-ALL) remains unknown. Moreover, Bcl-2-associated athanogene (BAG)2 is highly expressed a various tumors and regarded as an anti-apoptotic gene. In the present study, roles miR-325 BAG2 T-ALL line (Jurkat cells) were investiga...

Purpose The purpose of this study was to optimize a peptide (nABP284) that binds programmed cell death protein 1 (PD-1) by computer-based protocol in order increase its affinity. Then, aimed determine the inhibitory effects on cancer immune escape coculturing improving cytokine-induced killer (ICIK) cells with cells. Materials and Methods nABP284 PD-1 identified phage display technology our pre...

5-Aminoimidazole-4-carboxamide (AICA) riboside, a precursor of purine nucleotide biosynthesis, induces apoptosis in Jurkat cells. Incorporation of AICAriboside into the cells is necessary for this effect since addition of nitrobenzylthioinosine, a nucleoside-transport inhibitor, completely protects Jurkat cells from apoptosis. Adenosine, but not other nucleosides, also protects Jurkat cells fro...

BACKGROUND AND PURPOSE Allergic inflammation and autoimmune diseases, such as atopic dermatitis, psoriasis and multiple sclerosis (MS), involve both mast cell and T-cell activation. However, possible interactions between the two and the mechanism of such activations are largely unknown. EXPERIMENTAL APPROACH Human umbilical cord blood-derived cultured mast cells (hCBMCs) and Jurkat T cells we...

Objective(s): T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignant tumor. Administration of chemical compounds influencing apoptosis and T cell development has been discussed as promising novel therapeutic strategies. Valproic acid (VPA) as a recently emerged anti-neoplastic histone deacetylase (HDAC) inhibitor and pioglitazone (PGZ) as a high-affinity peroxisome p...

HIGHLIGHTS Eucalyptus cinerea essential oil (EO) contains 1,8-cineole as the main component. This EO demonstrated antioxidant and antimicrobial properties. reduced viability of Jurkat Calu-3 cells decreased DNA content. had cell death mechanism related to apoptosis.