The objective of this study was to evaluate the influence of oxatomide β-cyclodextrin inclusion complex on the physicochemical properties and bioavailability of the drug. Oxatomide β-cyclodextrin solid complex was prepared with equimolar ratio of both oxatomide and β-cyclodextrin in presence or absence of water soluble polymers using different techniques. The coevaporated complex prepared in pr...

Kaposi's sarcoma (KS)-associated herpesvirus or human herpesvirus 8 (HHV8) DNA is found consistently in nearly all classical, endemic, transplant, and AIDS-associated KS lesions, as well as in several AIDS-associated lymphomas. We have previously sequenced the genes for the highly variable open reading frame K1 (ORF-K1) protein from more than 60 different HHV8 samples and demonstrated that they...

the main objective of the present study was to formulate gastroretentive effervescent sustained release drug delivery systems of risperidone floating tablets with the help of methocel® k15, ethocel® standard 7fp premium, eudragit ® rs100 sustained release polymers to improve its safety profile, bioavailability and patient compliance. risperidone floating tablets were formulated by wet granulati...

PURPOSE To examine the expression of putative limbal epithelial stem cell (LESC) markers and wound healing rates in primary healthy and diabetic human limbal epithelial cells (LECs) cultured on different substrata. METHODS Primary limbal epithelial cells were isolated from human autopsy corneas and discarded corneoscleral rims with dispase II treatment. LECs were cultured in EpiLife medium on...

A monoclonal antibody (MoAb) K15 (IgG3) was obtained by fusion between SP2/0, mouse myeloma cell line and spleen cells from BC3Fl mice immunized with K562. a chronic myelocytic leukemia (CML) blastic crisis cell line. MoAb Kl5 precipitated a 21 kilodalton (KD) polypeptide in reduced condition. It stained lymphocytes, monocytes, eosinophiles and small bone marrow cells, but not neutrophiles, pla...

Taxanes like paclitaxel (PTX) cause severe and often permanent chemotherapy-induced alopecia (CIA). We have previously shown that PTX damages human scalp hair follicles (HFs) by inducing massive mitotic defects apoptosis in matrix (HM) keratinocytes as well bulge stem cell DNA damage, pharmacological induction of transient G1 arrest can be HF- cell-protective. tested whether ALRN-6924 protect H...

We show how the Delsarte theory can be used to obtain a linear programming bound for orthogonal arrays with mixed levels. Even for strength 2 this improves on the Rao bound in a large number of cases. The results point to several interesting sets of parameters for which the existence of the arrays is at present undecided. A M S classification: 05 B15; 62 K15