Breast cancer is classified into different subtypes that are associated with different patient survival outcomes, underscoring the importance of understanding the role of precursor cell and genetic alterations in determining tumor subtypes. In this study, we evaluated the oncogenic phenotype of two distinct mammary stem/progenitor cell types designated as K5+/K19- or K5+/K19+ upon introduction ...

PURPOSE Plasminogen kringle 5 (K5) is a potent angiogenic inhibitor and specifically binds to the voltage-dependent anion channel believed to function as the K5 receptor (K5R). To investigate the role of K5R in diabetic retinopathy, the present study measured the expression levels of K5R in the retina of diabetic retinopathy models. In cultured retinal Müller cells, K5 inhibited vascular endoth...

We prove that, for every integer k ≥ 2, every graph has an edge-partition into 5k log k sets, each of which is the edge-set of a graph with all degrees congruent to 1 mod k. This answers a question of Pyber. Pyber [8] proved that every graph G has an edge-partition into four sets, each of which is the edge set of a graph with all degrees odd; if every component of G has even order then three se...

·Ve introduce a new Gcn(zen-style framework of grafted hypc1rsequents that com\Jim's the fornrnlism of nested sequents with that of hyperscquents. To illustrate the potential of the frmnework. we present novel calculi for the modal logics K5 and KD5, m; well as for extensions of the modal logics K and KD with tlw axiom for shift rdlcxivity. Tlw latter of these extensions is also known as SDL + ...

The Ramsey number r(G,H) is determined for all disconnected (isolatefree) graphs H of order six and all graphs G of order at most five, except the three cases (G,H) ∈ {(K5 − 2K2, 2K3), (K5 − e, 2K3), (K5, 2K3)} where bounds with difference 1 are established. Moreover, general results are obtained for some small disconnected graphs H and any graph G.

Heparin and low molecular weight heparins may reduce brain damage evoked by ischaemia/reperfusion (I/R) injury, although their use is hampered by the risk of haemorrhage. Chemical and enzymatic modifications of K5 polysaccharide have shown the possibility to produce heparin-like compounds with low anticoagulant activity and strong anti-inflammatory effects. Using a rat model of transient cerebr...

Tetherin (CD317/BST2) is an interferon-induced membrane protein that inhibits the release of diverse enveloped viral particles. Several mammalian viruses have evolved countermeasures that inactivate tetherin, with the prototype being the HIV-1 Vpu protein. Here we show that the human herpesvirus Kaposi's sarcoma-associated herpesvirus (KSHV) is sensitive to tetherin restriction and its activity...

RBT-K5 cell line was established from a male Wistar rat bladder tumor induced with N-butyl-N-(4-hydroxybutyl) nitrosamine. RBT-K5 (ADM res.) cell line, adriamycin (ADM) resistant, was also established from RBT-K5 cells by stepwise escalation of ADM concentrations in vitro. In this study, we have examined the effect of verapamil (VR) on intracellular ADM concentration in these cell lines. The vi...