introduction: direction and latency of electrical connectivity between different sites of brain explains brain neural functionality. we compared efficiency of cross correlation and phase locking methods in time lag estimation which are based on local field potential (lfp) and lfpspike signals, respectively. methods: signals recorded from mt area of a macaque’s brain was used in a simulation app...

Calibration of model is critical for hydrologic modeling of large watersheds in a mountain watershed. In this study Soil and Water Assessment Tool (SWAT) used to comparison a single-site calibration procedure that employed streamflow measurement at outlet of watershed to a multi-site calibration method that used streamflow measurements at three stations (Galinak, Joestan and Dehdar). Results sh...

mammalian expression systems, due to their capacity in post-translational modification, are preferred systems for biopharmaceutical protein production. several recombinant protein systems have been introduced to the market, most of which are under clinical development. in spite of significant improvements such as cell line engineering, introducing novel expression methods, gene silencing and pr...

hypohidrotic ectodermal dysplasia (hed) is a rare congenital disorder arising from deficient development of ectoderm-derived structures including skin, nails, glands and teeth. the phenotype of hed is associated with mutation in eda, edar, edaradd and nemo genes, all of them disruptingnf-κb signaling cascade necessary for initiation, formation and differentiation in the embryo and adult. here w...

objectives: behavioral-based safety is a term used to describe the prevention of accidents, injuries and loss in the workplace. an effective behavior-based safety program relies on engaging employees to understand how unsafe behaviors lead to injuries and how to eliminate them from the workplace. this paper examines behavior-based safety program in a massive construction site. methods: for this...

Closure of donor site of the flap has special problems. Reduction of this site will decrease the morbidity of operation. In this study, we present our experience in donor site size reduction. METHODS Between 2006 and 2008, 15 patients with skin and soft tissue defects underwent operation. In all patients, coverage of defect was performed with various flaps. Substratum horizontal mat-tress sut...

this paper presents the criteria and applied methods in the screening of potential sites for the wastewater treatment plant of the falavarjan district, northwest of esfahan province. for this the nine parameters that were selected as main criteria, 7 parameters were considered to define the buffer zones in the natural and artificial terrains. at the first stage of the study, unsuitable zones we...

derivatives of phenyl-keto butenoic acids have been reported to be inhibitors of pyruvate decarboxylase, (pdc). the inhibition of transketolase, a thiamine requiring enzyme such as pdf, by meta nitrophenyl derivative of 2-oxo-3-butenoic acid (mnpb) is reported here. these studies indicate that the inhibitor binds to the enzyme at the active site. a two-step inhibition was observed, first the in...