GENE HUNTING, SIGNALING NETWORK, AND MOLECULAR MEDICINE In the 20th century, most researchers investigated WNT signaling in cell and developmental biology by using model animals, such as Drosophila, Xenopus, and mouse. However, I was confident that WNT signaling should be investigated for clinical application by using human samples or cell lines. In 1998, I, together with post-doctoral fellows,...

Cells of the innate immune system, including dendritic cells (DCs) and macrophages, have an important role in regulating the nature and magnitude of adaptive immune responses1. They recognize microbial components via pattern-recognition receptors, including various Tolllike receptors (TLRs), which trigger intracellular signaling events that induce the maturation and function of these cells. DCs...

•Aberrant acetylated regions (AARs) are an epigenetic barrier in SCNT embryos•TSA partly fixes AARs but is restricted by native epi-environments donor cells•Dux restores H3K9ac occupancy, drives 2C activation, and improves efficiency•Rescue efficiency Kdm4b TSA largely relies on Dux cluster activation Differentiated somatic cells can be reprogrammed to totipotent embryos through cell nuclear tr...