Background: The development of anti-red blood cell alloantibodies remains a major problem in transfusion of blood in thalassemia major patients. Also, Autoantibodies can result in clinical hemolysis and difficulty in cross-matching blood. We studied the frequency of red blood cell alloimmunization and autoimmunization among thalassemia patients who received regular transfusions in Ilam province...

In addition to its importance in transfusion, Kell protein is a member of the M13 family of zinc endopeptidases and functions as an endothelin-3-converting enzyme. To obtain information on the structure of Kell protein we built a model based on the crystal structure of the ectodomain of neutral endopeptidase 24.11 (NEP). Similar to NEP, the Kell protein has 2 globular domains consisting mostly ...

Genes located on the unpaired portion of the humanX chromosome can readily be recognized, but as far as the autosomes are concerned it is not known upon which autosome any human gene is located. The common variety of mongolism is characterized by 21-trisomy, and offers a possible approach to the localization ofhuman autosomal genes. The model on which this approach is based was first formulated...

OBJECTIVE To evaluate neonatal outcome in Kell haemolytic disease compared to Rh D haemolytic disease. STUDY DESIGN Retrospective study of all (near)-term neonates with Kell (n=34) and Rh D haemolytic disease (n=157) admitted to our centre between January 2000 and December 2008. We recorded the need for exchange transfusion and top-up transfusions up to 3 months of age. RESULTS Neonates in ...

OBJECTIVE To assess the Rhesus (Rh) and Kell (K) phenotype of voluntary blood donors and lay foundation of a data bank of voluntary blood donors. STUDY DESIGN Cross-sectional study. PLACE AND DURATION OF STUDY Blood Bank, The Aga Khan University Hospital, Karachi, in the year 2014. METHODOLOGY Voluntary blood donors were inducted after taking written informed consent. Three -5cc of EDTA a...

Kell is one of the major blood group systems in human erythrocytes. It is a complex system containing a large number of different antigens. Previously we cloned the Kell cDNA, which was predicted to encode an integral membrane protein with 731 amino acids. Now we have isolated overlapping genomic clones and determined the exon-intron structure of the KEL gene; it spans approximately 21.5 kb wit...

Erythroblastosis fetalis is a severe hemolytic disease in the newborn that originates in utero because of a maternal-fetal blood incompatibility. An unusual case of erythroblastosis fetalis caused by an irregular antibody of the Kell blood group is presented. The dental findings are compared to those found with Rh(D) incompatibility.

OBJECTIVE We here report the first study on the distribution of red cell antigens and phenotype frequencies of various blood group systems in Maldives. METHOD Randomly selected 123 regular blood donors of O group were phenotyped for seven blood group systems by direct tube agglutination and or indirect antiglobulin tests. Blood group systems studied were Rh, Kidd, Duffy, Lewis, Kell, P and MN...

The clinical manifestations of hemolytic disease of the fetus and newborn mediated by anti-K, an antibody of the Kell blood group system, have features that are distinguishable from the classical form of the disease. Affected fetuses may have low numbers of circulating reticulocytes. As well, antibody titers and amniotic fluid bilirubin levels are not reliable predictors of anemia. These observ...