The Nara Bladder Tumor No. 2 cell line, established from a urinary bladder carcinoma in the Wistar rat, formed keratinizing cells and multicellular pearls in meniscus gradient culture when fed with a medium of 15 or 30% fetal calf serum in Eagle's minimal essential medium. Confluent monolayer cultures were first prepared with the tubes in conventional horizontal position. When cultures were the...

Collections of exfoliated cells on Millipore filters, which retain the topographical relationships of the cells collected, previously have been used to examine keratinization and inflammation of adult gingivae. In the present study, samples of epithelial and inflammatory cells were obtained from the anterior maxillary gingivae of threeto five-year-old children using this technique. The oral hyg...

Twenty-four cases of giant condyloma acuminata were found among 100 cases diagnosed as carcinoma of the penis. One of the 24 tumours showed early malignant change. The characteristic histological pattern of giant condyloma consists of broad processes composed of prickle cells associated with little keratinization. The malignant condylomas show, in comparison, a loss of prickle cell preponderanc...

Oral mucosa becomes thinner, smooth and looses stippling aspect with aging. From histological standpoint appears: narrowing and alteration of gingival epithelium, modification of epithelial-connective interface and decreasing of keratinization. However, it cannot be detected significant histological alterations in size, shape or arrangement of epithelial cells that could be endorsed to aging pr...

SYNOPSIS Twenty-four cases of giant condyloma acuminata were found among 100 cases diagnosed as carcinoma of the penis. One of the 24 tumours showed early malignant change. The characteristic histological pattern of giant condyloma consists of broad processes composed of prickle cells associated with little keratinization. The malignant condylomas show, in comparison, a loss of prickle cell pre...

62 Indian Dermatology Online Journal | Volume 9 | Issue 1 | January‐February 2018 Sir, Darier disease [DD; Darier‐White disease or (dys) keratosis follicularis], is an autosomal dominant disorder of keratinization with characteristic dermatologic findings such as keratotic papules on the seborrheic regions, brittle nails and longitudinal erythronychia, and palmoplantar pitting. Hypopigmented ma...

Sites of synthesis of sulfur-containing protein in keratinizing epithelium have been studied by radioautography after injection of sulfur-labeled cystine. Bern et al. (3) demonstrated concentration of silver grains immediately below the cornified layer, suggesting that much of sulfur is added at the final stages of keratinization as observed in hair. In contrast, B6langer (4) reported that prot...