Objective: This research aimed to make ketoconazole spherical crystals improve the micromeritic properties and dissolution rate using solvent change method.
 Methods: The that is used in process of crystallization consists three types: ether (good solvent), distilled water (bad n-hexane (bridging liquid), with a 20:70:10 ratio each. agglomerates were characterized by differential scanning ...

AIM Denture stomatitis is a common and recurring problem of denture wearers. Ketoconazole tablet is one of the antimycotic drugs that often has been used to treat this condition, but systemic use of this drug has some adverse effects that frequently lead to unfavorable compliance and treatment failure. This study was designed to compare the efficacy of topical ketoconazole 2% in orabase and ket...

PURPOSE Ketoconazole has been shown to inhibit the glucuronidation of the UGT2B7 substrates zidovudine and lorazepam. Its effect on UGT1A substrates is unclear. A recent study found that coadministration of irinotecan and ketoconazole led to a significant increase in the formation of SN-38 (7-ethyl-10-hydroxycamptothecine), an UGT1A substrate. This study investigates whether ketoconazole contri...

BACKGROUND The antifungal compound ketoconazole has, in addition to its ability to interfere with fungal ergosterol synthesis, effects upon other enzymes including human CYP3A4, CYP17, lipoxygenase and thromboxane synthetase. In the present study, we have investigated whether ketoconazole affects the cellular uptake and hydrolysis of the endogenous cannabinoid receptor ligand anandamide (AEA). ...

The effect of ketoconazole on growth, sterol composition, in vitro sterol biosynthesis and P450-CO complex formation and its interaction with microsomal P450 was determined. On solid medium and in liquid medium ketoconazole inhibited Aspergillus fumigatus growth completely at 5 x 10(-5) M and 50% of the growth at 1.3 x 10(-5) M and 2.1 x 10(-5) M respectively. A close relationship between accum...

Prior to the development of ketoconazole, the treatment of systemic histoplasmosis and blastomycosis was limited to AMB. The convenience of oral dosing, combined with avoidance of the significant toxicities associated with AMB, make ketoconazole an attractive alternative for the treatment of selected forms of histoplasmosis and blastomycosis. Although high-dose (800 mg/day) ketoconazole is gene...

Background: Tinea versicolor is a common superficial mycosis, which is caused by lipophilic yeasts, malessezia furfur. It is a chronic and recurrent skin disease. It occurs most commonly in young post-pubertal people and in hot and humid climates (North and south provinces of Iran). Objective: Comparison of effects of ketoconazole 2% shampoo (Shafa Lab) with selenium sulfide 2.5% shampoo on tin...