The effects of ketotifen fumarate (KF) and clemastine fumarate (CF) on neutrophil chemiluminescent (CL) responses to zymosan particles coated with either IgG (IgGZ), C3 (C3Z), or both (IC3Z), were examined in vitro. These opsonized zymosans caused not only detectable neutrophil superoxide anion generation evaluated by an MCLA-dependent CL (MDCL) assay, with the order of light emission being IC3...

The antiallergic drug ketotifen is chiral due to a nonplanar seven-membered ring containing a keto group. Earlier studies have revealed glucuronidation at the tertiary amino group as a major metabolic pathway in humans. Chemical synthesis of glucuronides from racemic ketotifen now led to four isomers separable by HPLC of which two each could be ascribed to (R)-(+)- and (S)-(-)-ketotifen by synt...

BACKGROUND Oral immunotherapy (OIT) has shown promise in inducing desensitization for food allergy. However, there are safety concerns regarding the frequency and severity of adverse events during food OIT. OBJECTIVE To evaluate the effect of Ketotifen premedication on adverse reactions during peanut OIT. METHODS A randomized single blind placebo controlled pilot study was performed. Peanut...

This research has studied equilibrium adsorption isotherms of Ketotifen on carbon nanotube. And also results of experiments through Freundlich,Temkin and Langmuir models have been studied and it has found different parameters of these models for carbon nano-tube adsorbent. According to the error rate for each model, we obtained a good agreement between these data which it showed the best agreem...