نتایج جستجو برای: keywords aptamer

تعداد نتایج: 1982596  

Journal: :Community Literacy Journal 2010

Journal: :Romanticism and Victorianism on the Net: 2007

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Lele Li Rong Tong Hunghao Chu Weiping Wang Robert Langer Daniel S Kohane

The in vivo application of aptamers as therapeutics could be improved by enhancing target-specific accumulation while minimizing off-target uptake. We designed a light-triggered system that permits spatiotemporal regulation of aptamer activity in vitro and in vivo. Cell binding by the aptamer was prevented by hybridizing the aptamer to a photo-labile complementary oligonucleotide. Upon irradiat...

2010
Yusuke Nomura Shigeru Sugiyama Taiichi Sakamoto Shin Miyakawa Hiroaki Adachi Kazufumi Takano Satoshi Murakami Tsuyoshi Inoue Yusuke Mori Yoshikazu Nakamura Hiroyoshi Matsumura

Aptamers are short single-stranded nucleic acids with high affinity to target molecules and are applicable to therapeutics and diagnostics. Regardless of an increasing number of reported aptamers, the structural basis of the interaction of RNA aptamer with proteins is poorly understood. Here, we determined the 2.15 Å crystal structure of the Fc fragment of human IgG1 (hFc1) complexed with an an...

Journal: :SCIENTIA SINICA Chimica 2018

2014
Thuy Ngoc Le Tok Wang Ling H. V. Jagadish Jiaheng Lu

It is well known that some XML elements correspond to objects (in the sense of object-orientation) and others do not. The question we consider in this paper is what benefits we can derive from paying attention to such object semantics, particularly for the problem of keyword queries. Keyword queries against XML data have been studied extensively in recent years, with several lowest-common-ances...

Journal: :Journal of molecular recognition : JMR 2009
Xing Zhang Ajish S R Potty George W Jackson Victor Stepanov Andrew Tang Yamei Liu Katerina Kourentzi Ulrich Strych George E Fox Richard C Willson

In previous work, Vibrio proteolyticus 5S rRNA was shown to stabilize 13-50 nucleotide "guest" RNA sequences for expression in Escherichia coli. The expressed chimeric RNAs accumulated to high levels in E. coli without being incorporated into ribosomes and without obvious effects on the host cells. In this work, we inserted sequences encoding known aptamers recognizing a protein and an organic ...

Journal: :Biomaterials 2013
Li Cai Ze-Zhong Chen Min-Yan Chen Hong-Wu Tang Dai-Wen Pang

In this work, we have prepared three types of aptamer-conjugated Rubpy-doped silica nanoparticles for Human breast carcinoma MCF-7 cells labeling. Probe A is prepared through covalent conjugation between amine-labeled MUC-1 aptamer and carboxyl-modified Rubpy-doped NPs (NPs-aptamer). Probe B is prepared based on the interaction between biotin-labeled MUC-1 aptamer and avidin-conjugated Rubpy-do...

2011
Annekathrin Haberland Gerd Wallukat Claudia Dahmen Andreas Kage Ingolf Schimke

Rationale: Autoantibodies directed against the beta1-adrenoceptor (beta1-AABs) have been proposed to drive the pathogenesis of idiopathic dilated cardiomyoparthy (DCM), Chagas’ cardiomyopathy, and peripartum cardiomyopathy. For disease treatment, aptamers that bind and neutralize beta1-AABs could be significant. Objective: We determined whether oligonucleotide-aptamers, selected to target human...

2017
Yong-Boum Kim Anna Wacker Karl von Laer Vladimir V. Rogov Beatrix Suess Harald Schwalbe

The mfl-riboswitch is a transcriptional off-switch, which down-regulates expression of subunit β of ribonucleotide reductase in Mesoplasma florum upon 2΄-deoxyguanosine binding. We characterized binding of 2΄-deoxyguanosine to the mfl-aptamer domain (WT aptamer) and a sequence-stabilized aptamer (MT aptamer) under in vitro and 'in-cell-like' conditions by isothermal titration calorimetry (ITC) ...

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