INTRODUCTION Diabetic nephropathy is the leading cause of chronic kidney disease (CKD) and end-stage renal disease.1 It is characterized by initial hyperfiltration, albuminuria, thickening of the basement-membranes, expansion of the mesangial matrix, and subsequent loss of kidney function.2 Reactive oxygen species (ROS) include superoxide anion, hydrogen peroxide, and hydroxyl radical. Reactive...

Benign multilocular cyst is a rare benign multicystic renal tumor. It usually involves the kidneys unilaterally. There is no generally accepted theory concerning its pathogenesis. The usual clinical presentation is an asymptomatic abdominal mass in children and nonspecific symptoms such as abdominal pain, hematuria, and urinary tract infection in adults. This report presents a case of benign mu...

Introduction. This study was aimed to assess the ratio of total cholesterol (TC) to high-density density lipoprotein cholesterol (HDLC) and plasma nitrate levels in patients with ischemic nephropathy receiving statins and niacin extended release (NER). Materials and Methods. Kidney disease patients with a history of at least 5 year of diabetes mellitus or 10 year of hypertension were screened b...

Introduction. Fibroblast growth factor 2 (FGF2) is a potent mitogenic factor of cortical fibroblasts and induces kidney fibrosis. We hypothesized that serum levels of FGF2 has an association with the severity of vesicoureteral reflux (VUR) and renal parenchymal scar. Materials and Methods. Between 2007 and 2009, a total of 28 children with VUR were enrolled in this study and were compared with ...

Introduction. We assessed whether cosupplementation of vitamins C and E has additive beneficial effects on reducing the kidney damage and attenuation of the arterial pressure elevation compared to administration of either vitamin C or vitamin E alone in deoxycorticosterone acetate-salt-induced hypertension. Materials and Methods. Forty rats were divided into 4 study groups and 1 sham-operated g...

Introduction. Leukocyte count, erythrocyte sediment rate and C-reactive protein are available laboratory markers which may be helpful in prediction of technetium Tc 99m dimercaptosuccinic acid (DMSA) renal scintigraphy results. None of these, however, have enough accuracy for prediction of renal injury and scar. This study was aimed to evaluate the diagnostic accuracy of urinary β2-microglobuli...

Introduction. Risk factors of renal involvement in Henoch-Schonlein nephritis (HSN) have been extensively studied, but their relations with the severity of glomerular lesions at the disease onset are much less known. Materials and Methods. Data were collected retrospectively on 45 patients (age range, 2 to 15 years) with HSN to identify the initial clinical and laboratory features that most acc...

Drug-induced acute interstitial nephritis (DAIN) is a common cause of acute kidney injury and often presents as an unexplained rise in serum creatinine level. Kidney biopsy is therefore frequently required to make a definitive diagnosis. The hallmark pathologic features of DAIN are interstitial edema, interstitial inflammation, and tubulitis with a predominance of CD4+ T lymphocytes and mononuc...

background elevated serum gamma-glutamyltransferase (ggt) is predictive of various cardiovascular (cv) risk factors including chronic kidney disease (ckd). elevated serum ggt has been recognized in smokers who are likely to develop ckd, but no study has focused on serum ggt and ckd in smokers. objectives the aim of this study was to clarify the associations between cigarette consumption, elevat...

Chronic kidney disease represents a dramatic worldwide resourceconsuming problem. This problem is of increasing importance even in preterm infants, since nephrogenesis may go on only for a few weeks (4 to 6 weeks) after birth. Recent literature focusing on traditional regenerative medicine does not take into account the presence of a high number of active endogenous stem cells in the preterm ki...