5-Aminolaevulinic acid dehydratase (ALAD) is an essential enzyme in most organisms, catalysing an inaugural step in the tetrapyrrole biosynthetic pathway, the Knorr-type condensation reaction of two molecules of 5-aminolaevulinic acid (ALA) to form the monopyrrole porphobilinogen. ALADs can be conveniently separated into two main groups: those requiring Zn2+ for activity (typified here by the e...

A new electron-transfer mediator, 5-[2,5-di (thiophen-2-yl)-1H-pyrrol-1-yl]-1,10-phenanthroline iron(III) chloride (FePhenTPy) oriented to the nicotinamide adenine dinucleotide-dependent-glucose dehydrogenase (NAD-GDH) system was synthesized through a Paal-Knorr condensation reaction. The structure of the mediator was confirmed by Fourier-transform infrared spectroscopy, proton and carbon nucle...

Quinoline scaffold are found in many natural products and they exhibit remarkable biological activities like Antimalerial, antibacterial, antiasthmatic, antihypertensive, anti-inflammatory agents and antiobesity. Aryl-substituted quinolines act as ligands for 5-lipoxygenase , tyrosine kinase , leukotriene 11 and other receptors. Furthermore, polyquinolines were shown to undergo hierarchical sel...

The title compound, C(17)H(26)O(10), was formed by a Koenigs-Knorr reaction of 2,3,4,6-tetra-O-acetyl-α-d-glucopyranosyl bromide and propan-2-ol. The central ring adopts a chair conformation. The crystal does not contain any significant inter-molecular inter-actions.

A conceptually novel nanoparticle-supported and magnetically recoverable organocatalyst has been developed, which is readily prepared from inexpensive starting materials in a truly sustainable manner; which catalyzes the Paal-Knorr reaction with high yield in pure aqueous medium that avoids the use of toxic organic solvents, even in the workup step.

The first synthesis of marinopyrrole B, which is highly active against methicillin-resistant Staphylococcus aureus, is described. The route involved constructing a pyrrole ring on the nitrogen of a 3-bromo-4,5-dichloropyrrole by N-alkylation with a special Michael acceptor having an allylic leaving group; the second pyrrole ring was then formed by a Paal-Knorr reaction.

1 Limnological Research Station and Department of Hydrology, University of Bayreuth, Universitätsstraße 30, 95440 Bayreuth, Germany 2 Department of Soil Physics, University of Bayreuth, Universitätsstraße 30, 95440 Bayreuth, Germany Received: 27 February 2008 – Accepted: 27 February 2008 – Published: 2 April 2008 Correspondence to: K.-H. Knorr ([email protected]) Published by Copernicus ...