vilsmeier several diamide derivatives containing 2-chloroquinoline scaffolds were synthesized via ugi reaction of 2-chloroquinoline-3-carboxaldehydes, amines, carboxylic acids and isocyanides. the diversity of these quinolinyl ugi-adducts was increased by using 2-chloroquinoline-3-carboxylic acids as a source of acid. among them, compounds 2d, 2n, 2p, 4a, 4c and 4e displayed moderate to good an...

introduction: for a successful root canal treatment, canal must be obturated apically, coronally and laterally to prevent microleakage and canal reinfection. cold lateral condensation is the most popular method of canal obturation; an easy method with a controlled filling. cold lateral technique disadvantages are presence of void, possible vertical root fracture, and absence of a homogenous and...

he movements of cilia and flagella are driven by axonemal dynein ATPases, whose activity must be coordinated in space and time. On page 47, Rupp and Porter provide the first molecular characterization of a component of the dynein regulatory complex (DRC), a crucial but poorly understood regulator of flagellar movement. Besides suggesting a model for DRC assembly, the work identifies a possible ...

Works intended for this column should be sent direct to the Book-Review Editor, whose address appears in this issue. All reviews are also available from Crystallography Journals Online, supplemented where possible with direct links to the publisher's information. The following books have been received by the Editor. Uncritical notices are given under this heading instead of reviews in order to ...

Using magnetic tweezers, we study in real time the condensation of single DNA molecules under tension. We find that DNA condensation occurs via discrete nucleated events. By measuring the influence of an imposed twist, we show that condensation is initiated by the formation of a plectonemic supercoil. This demonstrates a strong interplay between the condensation transition and externally impose...