it has been proposed that appearance of amyloid beta (aβ) in hippocampus is one of the characteristic features of alzheimer’s disease (ad). the role of nitric oxide (no) in neurodegenerative disorders is controversy in different contexts. here, we examined the effect of no on spatial memory. for this purpose, we compared the effects of three different concentrations of l-ng-nitroarginine methyl...

background: the blocking of nitric oxide synthase (nos) activity may reason vasoconstriction with formation of reactive oxygen species. propolis has biological and pharmacological properties, such as antioxidant. the aim of this study was to examine the antioxidant effects of propolis which natural product on biochemical parameters in brain and lung tissues of acute nitric oxide synthase inhibi...

angiotensin-converting enzyme (ace) inhibitors including quinapril could exert a protective effect on cardiovascular system through endothelial system in normoglycemic and diabetic rats. the present experimental work was designed to study the vascular reactivity of aortic ring segments isolated from streptozotocin (stz)-diabetic rats treated for 4 weeks with nitro-l-arginine-methyl ester (l-nam...

background: the petal’s hydro‑alcoholic extract of rosa damascena mill. on ileum contractions of wistar rats and its possible mechanism were investigated. methods: forty‑eight male wistar rats were divided into six groups. ileum was placed adjacent to propranolol (1 μm), naloxone (1 μm) and l‑name (100 μm) and also under the influence of different doses (2-8 mm) of calcium chloride. results: cu...

background: ferula persica has been used in traditional medicine for treatment of high blood pressure. in this study acute and chronic effect of aqueous f. persica extract on bp of hypertensive rats and its possible mechanism of action have been investigated. methods: eighty two male wistar rats were divided into 12 experimental groups. hypertension was induced by goldblatt method in the anesth...

introduction: iron overload has been implicated as an important factor for nephropathy by hydroxyl radicals production. on the other hand nitric oxide (no) asa reactive free radical, has numerous effects on kidney. however at high concentration it has been suggested to have toxic effects. in this study the interaction between iron overload and no system on renal function were evaluated in rats....

Angiotensin-converting enzyme (ACE) inhibitors including quinapril could exert a protective effect on cardiovascular system through endothelial system in normoglycemic and diabetic rats. The present experimental work was designed to study the vascular reactivity of aortic ring segments isolated from streptozotocin (STZ)-diabetic rats treated for 4 weeks with nitro-L-arginine-methyl ester (L-NAM...

introduction: this study was conducted to determine the possible beneficial results of l-arginine on prefrontal cortex of rats which impressed by immobilization stress to define the synchronous impression of stress and nitric oxide (no) on evolution of prefrontal cortex of rats after birth. methods: forty-eight one month, male wistar rats were divided into two groups: stressed and non-stressed....