Mexiletine, l-methyl-Z(2,6-xylyloxy)ethylamine hydrochloride (Mexitil@ ), has been shown to suppress markedly ventricular rhythm disorders [l61. Effective serum levels of mexiletine range from ca. 0.5 to 2.0 pg/ml [24,7,8]. Although the antiarrhythmic efficacy of mexiletine is not correlated directly with its serum level [ 3,4,7,8], the determination of the drug is recommended when adverse effe...

The cultivation of special corns, such as baby corn, has had a positive influence on the economy country. Despite its importance, there is still need for studies aimed at increasing production and planting areas crop. Phytosanitary are particular interest, crops susceptible to series pathogens, Bipolaris maydis, Exserohilum turcicum, Puccinia polysora. use resistant cultivars most effective way...

In adult mammals, after optic nerve injury, retinal ganglion cells (RGCs) do not regenerate their axons and most of them die by apoptosis within a few days. Recently, several strategies that activate neuronal intracellular pathways were proposed to prevent such degenerative processes. The rho-related small GTPase Rac1 is part of a complex, still not fully understood, intracellular signaling net...

Phenyl radical has been studied via sub-Doppler infrared spectroscopy in a slit supersonic discharge expansion source, with assignments for the highest frequency b2 out-of-phase C-H symmetric stretch vibration (ν19) unambiguously confirmed by ≤6 MHz (0.0002 cm(-1)) agreement with microwave ground state combination differences of McMahon et al. [Astrophys. J. 2003, 590, L61-64]. Least squares an...

The current study examined sera from 160 colon cancer patients and 60 normal individuals to determine whether antibody to mutated p21 ras protein was present. Studies focused on the aspartic acid substitution at amino acid position 12 (denoted D12), one of the most common mutations in colon adenocarcinoma. IgA antibodies directed against mutated p21 ras-D12 protein were detected in 51 (32%) of ...

This paper analyzes the increasing tariff protection in the Spanish iron and steel industry over the first third of the 20th century. Learning effects are explicitly included to model a dynamic game of trade liberalization. The government chooses the tariff level while firms decide how much to produce each period. Firm’s production decisions determine their future cost levels. Assuming that lea...

LdtR is a transcriptional activator involved in the regulation of a putative L,D transpeptidase in Liberibacter asiaticus, an unculturable pathogen and one of the causative agents of Huanglongbing disease. Using small molecule screens we identified benzbromarone as an inhibitor of LdtR activity, which was confirmed using in vivo and in vitro assays. Based on these previous results, the objectiv...

Since the discovery of the cystic fibrosis (CF) gene that encodes the CF transmembrane conductance regulator (CFTR) in 1989, there has been considerable progress in understanding the molecular defects associated with different mutations in the CFTR protein. Small molecule "potentiators" have led the way as a drug therapeutic approach for correcting channel gating mutations such as the G551D mut...

This paper examines the relationship between employment relations and American corporate governance using the case of Ferodyn*. In response to difficult industry conditions and sagging performance, American-owned Landis* Steel Corporation and Japanese-owned Daiichi* Steel Corporation jointly financed and built Ferodyn, a state-of-the-art high quality steel finishing facility. Although the joint...