Potent cytolytic activity was exhibited by proteins extracted from three sea anemones viz. Heteractis magnifica, Stichodactyla haddoni and Paracodylactis sinensis by affecting the red blood corpuscles (RBC) and the mouse fibroblast cell line (L929) and leukemia cell line (P388). Crude toxin of all the three anemone species induced spontaneous hemolysis of chicken, goat and human erythrocytes. T...

background: prostate cancer is one of the leading causes of cancer deaths among men. new gene expressed in prostate (ngep), is a prostate-specific gene expressed only in normal prostate and prostate cancer tissue. because of its selective expression in prostate cancer cell surface, ngep is a potential immunotherapeutic target. to target the ngep in prostate cancer, it is essential to investigat...

BACKGROUND It is extensively supposed that vegetarian diet could affect cancer progress and increase the influence of formal chemotherapy. OBJECTIVES The present study was designed to determine the effect of the ethanol Bane skin extract against chemo resistant prostate cancer PC3 cells. MATERIALS AND METHODS PC3 and L929 cells were cultivated and then incubated in the ethanol Bane skin ext...

Barium oxide nanoparticles (BaONPs) are an important industrial compound and are widely used in polymers and paints. In this study, apoptotic and genotoxic effects of BaONPs in mouse embryonic fibroblast (L929) cells were determined by using single-cell gel test. In vitro cytotoxicity assays were performed to assess BaONPs' toxicity in L929 cells. Mild cytotoxicity was observed in L929 cells du...

Formocresol is common treatment in exposed pulp of primary teeth at caries, trauma and damaged with cavity preparation. Although, clinical and radiographic success and good clinical results are observed, dentistry societies are still searching for materials interchangeable with formocresol. Suab1 is a phytochemical agent that was selected because of its anti- bleeding effect. In this study, we ...

background & objective: chlorhexidine solution is one of the widely used mouth antiseptic liquid that prevents teeth tissue damage and also has application as a root canal antiseptic. in this study, cytotoxicity of 2% chlorhexidine solution is compared with another root canal antiseptic, calcium hydroxide powder. materials and methods: cell cytotoxicity of both chemicals was assessed on culture...

The aim of this in vitro study was assessment the cytotoxic level 6-O-desmethylnaproxen. A mouse connective tissue fibroblast cell line, L929 exposed to naproxen and 6-O-desmethylnaproxen different concentrations for 24- 48- hours. Cell viability tested by MTT, while apoptosis determined AO/PI double staining method. control group free from any agent (DMEM only) accepted as 100% viability. IC50...

The existence of reliable mtDNA reference sequences for each species is of great relevance in a variety of fields, from phylogenetic and population genetics studies to pathogenetic determination of mtDNA variants in humans or in animal models of mtDNA-linked diseases. We present compelling evidence for the existence of sequencing errors on the current mouse mtDNA reference sequence. This includ...

Organisms in the genus Mycobacterium cause a variety of human diseases. One member of the genus, M. ulcerans, causes a necrotizing skin disease called Buruli ulcer. Buruli ulcer is unique among mycobacterial diseases in that the organisms at the site of infection are extracellular and there is little acute inflammatory response. Previous literature reported the presence of a toxin in the cultur...

shiga toxins (stxs) are bacterial virulence factors produced by shigella dysenteriae serotype 1 and escherichia coli strains. stxs are critical factors for the development of diseases such as severe bloody diarrhea and hemolytic uremic syndrome. additionally, stxs trigger the secretion of pro- inflammatory cytokines and chemokines, particularly in monocytes or macrophages. the inflammatory cyto...